3 documents found, page 1 of 1
Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) co...
Ribeiro, Nádia; Bulut, Ipek; Sergi, Baris; Pósa, Vivien; Spengler, Gabriella; Sciortino, Giuseppe; André, Vânia; Ferreira, Liliana P.; Biver, TaritaWe report the synthesis and characterization of a group of benzoylhydrazones (Ln) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH3, OCH3, OH and NH2, for L1-7, respectively; in L8 isonicotinohydrazide was used instead of benzylhydrazide). Cu(II) complexes were prepared by reaction of each benzoylhydrazone with Cu(II) acetate. All compou...
Increased antibacterial properties of indoline-derived phenolic Mannich bases
Rimpiläinen, Tatu; Nunes, Alexandra; Calado, Rita; Fernandes, Ana S.; Andrade, Joana; Ntungwe, Epole; Spengler, Gabriella; Szemerédi, NikolettaThe search for antibacterial agents for the combat of nosocomial infections is a timely problem, as antibiotic-resistant bacteria continue to thrive. The effect of indoline substituents on the antibacterial properties of aminoalkylphenols was studied, leading to the development of a library of compounds with minimum inhibitory concentrations (MICs) as low as 1.18 μM. Two novel aminoalkylphenols were identified ...
Evaluation of Cucurbitane-type Triterpenoids from Momordica balsamina on P-Glyc...
Spengler, Gabriella; Ramalhete, Catia; Martins, Marta; Martins, Ana; Serly, Julianna; Viveiros, Miguel; Molnar, Joseph; Duarte, Noelia; Mulhovo, SilvaBackground: Cancer cells become refractory to chemotherapy as a consequence of their overexpressing ABC transporters that extrude not only the therapeutic agent but other unrelated compounds such as chemotoxins and biocides before they can reach their intended targets. A compound that can inhibit the activity of these transporters may find use as an adjunct to chemotherapy that had been rendered ineffective. Ma...