3 documents found, page 1 of 1
Host immune genetic variations influence the risk of developing acute myeloid l...
Sánchez-Maldonado, J. M.; Campa, D.; Springer, J.; Badiola, J.; Niazi, Y.; Moñiz-Díez, A.; Hernández-Mohedo, F.; González-Sierra, P.; Ter Horst, R.The purpose of this study was to conduct a two-stage case control association study including 654 acute myeloid leukaemia (AML) patients and 3477 controls ascertained through the NuCLEAR consortium to evaluate the effect of 27 immune-related single nucleotide polymorphisms (SNPs) on AML risk. In a pooled analysis of cohort studies, we found that carriers of the IL13rs1295686A/A genotype had an increased risk of...
Multiplex PCR system for fungal pathogen detection
Pereira, Joana Isabel Carvalho; Springer, J.; Buítrago, M. J.; Löffler, J.; Pais, Célia; Sampaio, P.Introduction: The rapid and correct identification of pathogenic species is crucial for several reasons that differ according to the area of interest. In clinical laboratories it is important since knowing the pathogen guides appropriate treatment, dose and duration of therapy. In clinical microbiology laboratories culture and microscopic examination remain the “gold standard”. Biochemical and mass spectometry ...
Polymorphisms in host immunity modulating genes and risk of invasive aspergillo...
Lupiañez, C. B.; Canet, L. M.; Carvalho, Agostinho Albérico Rodrigues de; Alcazar-Fuolie, L.; Springer, J.; Lacknerg, M.; Segura-Catena, J.; Comino, A.Recent studies suggest that immune-modulating single nucleotide polymorphisms (SNPs) influence the risk of developing cancer-related infections. Here, we evaluated whether 36 SNPs within 14 immune-related genes are associated with the risk of Invasive Aspergillosis (IA) and whether genotyping of these variants might improve disease risk prediction. We conducted a case-control association study of 781 immunocomp...