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Host immune genetic variations influence the risk of developing acute myeloid l...

Sánchez-Maldonado, J. M.; Campa, D.; Springer, J.; Badiola, J.; Niazi, Y.; Moñiz-Díez, A.; Hernández-Mohedo, F.; González-Sierra, P.; Ter Horst, R.

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party ...


Multiplex PCR system for fungal pathogen detection

Pereira, Joana Isabel Carvalho; Springer, J.; Buítrago, M. J.; Löffler, J.; Pais, Célia; Sampaio, P.

Introduction: The rapid and correct identification of pathogenic species is crucial for several reasons that differ according to the area of interest. In clinical laboratories it is important since knowing the pathogen guides appropriate treatment, dose and duration of therapy. In clinical microbiology laboratories culture and microscopic examination remain the “gold standard”. Biochemical and mass spectometry ...


Polymorphisms in host immunity modulating genes and risk of invasive aspergillo...

Lupiañez, C. B.; Canet, L. M.; Carvalho, Agostinho Albérico Rodrigues de; Alcazar-Fuolie, L.; Springer, J.; Lacknerg, M.; Segura-Catena, J.; Comino, A.

Recent studies suggest that immune-modulating single nucleotide polymorphisms (SNPs) influence the risk of developing cancer-related infections. Here, we evaluated whether 36 SNPs within 14 immune-related genes are associated with the risk of Invasive Aspergillosis (IA) and whether genotyping of these variants might improve disease risk prediction. We conducted a case-control association study of 781 immunocomp...


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