8 documents found, page 1 of 1
Impairment in Social Cognition in People With Substance Use Disorders.
Piñón-Blanco, Adolfo; Rodrigues, Sonia; Teixeira, Joana; Coutinho, Catia; Faria, Isabela; Murta, Ilda; Tavares, Ana Isabel; Iglesias-Rejas, LuisIntroduction: Substance use disorders are associated with impairments in various neuropsychological functions. We evaluated potential alterations in social cognition and differences between men and women in individuals with substance use disorders undergoing treatment at Addiction and Dependency Intervention Centers in Portugal. Methods: The assessment utilized the Ekman 60 Faces Test (EFT), Interpersonal React...
An injectable composite co‐assembled dehydropeptide‐based magnetic/plasmonic li...
Veloso, Sérgio R. S.; Vázquez‐González, Margarita; Spuch, Carlos; Freiría‐Martínez, Luis; Comís‐Tuche, María; Iglesias‐Martínez‐Almeida, MartaAdvancing therapeutic effectiveness through the strategic co-delivery of drugs in a sequential manner represents a compelling strategy. However, achieving precise and selective release of chemotherapeutic agents remains a formidable challenge. In this study, a co-assembled Arginine-Glycine-Aspartate (RGD)-functionalized dehydropeptide-based gel loaded with magnetic liposomes and mesoporous silica-coated gold na...
New strategies for multimodal cancer therapy based on plasmonic lipogels
Veloso, Sérgio Rafael Silva; Sá, Filipa Costa e; Comís-Tuche, María; Spuch, Carlos; Castanheira, Elisabete M. S.Enhancing the therapeutic efficacy of chemotherapeutic agents through sequential drug delivery holds immense promise, yet current strategies are mainly dependent on the tumour microenvironment. Natural polymer-based hydrogels present suitable properties for these applications, owing to their inherent biocompatibility [1]. Herein, we present a novel strategy aimed at improving the tunability and real-time contro...
Sequential release of drugs from dual-delivery plasmonic nanogels containing li...
Costa-e-Sá, Filipa; Comís-Tuche, María; Spuch, Carlos; Castanheira, Elisabete M. S.; Veloso, Sérgio Rafael SilvaNanosystems that enable the sequential delivery of various drugs with different targets are desired for improved cancer therapy. However, current strategies are mainly dependent on the tumour microenvironment, such as low pH or enzyme-triggered release. In this work, a nanosystem design strategy for near infrared (NIR) light-triggered sequential delivery based on lipid-gated mesoporous silica-coated gold nanoro...
Tuning the drug multimodal release through a co-assembly strategy based on magn...
Veloso, Sergio R. S.; Tiryaki, Ecem; Spuch, Carlos; Hilliou, L.; Amorim, C. O.; Amaral, V. S.; Coutinho, Paulo J. G.; Ferreira, Paula M. T.Self-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a mode...
Tuning the drug multimodal release through a co-assembly strategy based on magn...
Veloso, Sérgio R. S.; Tiryaki, Ecem; Spuch, Carlos; Hilliou, Loic; Amorim, C. O.; Amaral, V. S.; Coutinho, Paulo J. G.; Ferreira, Paula M. T.Self-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a mode...
Rendimiento neuropsicológico de niños y niñas con Trastorno por Déficit de Aten...
Piñón-Blanco, Adolfo; Carballido, Elisa; Vázquez-Justo, Enrique; Gutiérrez Velas, Olga; Spuch, Carlos; Fernandes, Sara M.El trastorno por déficit de atención e hiperactividad (TDAH) ha sido comúnmente asociado a déficits en los subprocesos atencionales y en las funciones ejecutivas. El presente trabajo pretende estudiar el rendimiento cognitivo-ejecutivo de niños y niñas entre 8 y 15 años de edad con diagnóstico de TDAH, comparándolo con el rendimiento de un grupo normativo. La muestra total estaba compuesta por 47 participantes ...
The neurobiological hypothesis of neurotrophins in the pathophysiology of schiz...
Rodrigues-Amorim, Daniela; Rivera-Baltanás, Tania; Peixoto, João Miguel Seiça Bessa; Sousa, Nuno; Vallejo-Curto, María de CarmenSchizophrenia is associated with patterns of aberrant neurobiological circuitry. The disease complexity is mirrored by multiple biological interactions known to contribute to the disease pathology. One potential contributor is the family of neurotrophins which are proteins involved in multiple functional processes in the nervous system, with crucial roles in neurodevelopment, synaptogenesis and neuroplasticity....