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Ozone-related acute excess mortality projected to increase in the absence of cl...

Domingo, NGG; Fiore, AM; Lamarque, J-F; Kinney, PL; Jiang, L; Gasparrini, A; Breitner, S; Lavigne, E; Madureira, J; Masselot, P; Silva, SDNPD

Short-term exposure to ground-level ozone in cities is associated with increased mortality and is expected to worsen with climate and emission changes. However, no study has yet comprehensively assessed future ozone-related acute mortality across diverse geographic areas, various climate scenarios, and using CMIP6 multi-model ensembles, limiting our knowledge on future changes in global ozone-related acute mort...


Temporal variations in the short-term effects of ambient air pollution on cardi...

Schwarz, M; Peters, A; Stafoggia, M; de'Donato, F; Sera, F; Bell, ML; Guo, Y; Honda, Y; Huber, V; Jaakkola, JJK; Urban, A; Vicedo-Cabrera, AM

Background: Ambient air pollution, including particulate matter (such as PM10 and PM2·5) and nitrogen dioxide (NO2), has been linked to increases in mortality. Whether populations’ vulnerability to these pollutants has changed over time is unclear, and studies on this topic do not include multicountry analysis. We evaluated whether changes in exposure to air pollutants were associated with changes in mortality ...


Joint effect of heat and air pollution on mortality in 620 cities of 36 countries

Stafoggia, M; Michelozzi, P; Schneider, A; Armstrong, B; Scortichini, M; Rai, M; Achilleos, S; Alahmad, B; Analitis, A; Åström, C; Bell, ML; Calleja, N

Background The epidemiological evidence on the interaction between heat and ambient air pollution on mortality is still inconsistent. Objectives To investigate the interaction between heat and ambient air pollution on daily mortality in a large dataset of 620 cities from 36 countries. Methods We used daily data on all-cause mortality, air temperature, particulate matter ≤ 10 μm (PM10), PM ≤ 2.5 μm (PM2.5), nitr...


Differential Mortality Risks Associated With PM2.5 Components A Multi-Country, ...

Masselot, P; Sera, F; Schneider, R; Kan, H; Lavigne, É; Stafoggia, M; Tobias, A; Chen, H; Burnett, RT; Schwartz, J; Zanobetti, A; Bell, ML; Chen, B-Y

Background: The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality. Methods: We applied a 2-stage analysis on data collected from 210 locations in 16 countries. In the first stag...


Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mor...

Alahmad, B; Khraishah, H; Royé, D; Vicedo-Cabrera, AM; Guo, Y; Papatheodorou, SI; Achilleos, S; Acquaotta, F; Armstrong, B; Bell, ML; Pan, SC

Background: Cardiovascular disease is the leading cause of death worldwide. Existing studies on the association between temperatures and cardiovascular deaths have been limited in geographic zones and have generally considered associations with total cardiovascular deaths rather than cause-specific cardiovascular deaths. Methods: We used unified data collection protocols within the Multi-Country Multi-City Coll...


Mortality risk attributable to wildfire-related PM(2·5) pollution: a global tim...

Chen, G; Guo, Y; Yue, X; Tong, S; Gasparrini, A; Bell, ML; Armstrong, B; Schwartz, J; Jaakkola, JJK; Zanobetti, A; Lavigne, E; Nascimento Saldiva, PH

Background Many regions of the world are now facing more frequent and unprecedentedly large wildfires. However, the association between wildfire-related PM2·5 and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2·5 and mortality across various regions of the world. Methods For this time series study, data on daily co...


Ambient carbon monoxide and daily mortality: a global time-series study in 337 ...

Chen, K; Breitner, S; Wolf, K; Stafoggia, M; Sera, F; Vicedo-Cabrera, AM; Guo, Y; Tong, S; Lavigne, E; Matus, P; Valdés, N; Kan, H; Jaakkola, JJK

Background. Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a ...


Short term association between ozone and mortality: global two stage time serie...

Vicedo-Cabrera, AM; Sera, F; Liu, C; Armstrong, B; Milojevic, A; Guo, Y; Tong, S; Lavigne, E; Kyselý, J; Urban, A; Orru, H; Indermitte, E; Pascal, M

Objective: To assess short term mortality risks and excess mortality associated with exposure to ozone in several cities worldwide. Design: Two stage time series analysis. Setting: 406 cities in 20 countries, with overlapping periods between 1985 and 2015, collected from the database of Multi-City Multi-Country Collaborative Research Network. Population Deaths for all causes or for external causes only register...


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