2 documents found, page 1 of 1
Mn-based methacrylated gellan gum hydrogels for MRI-guided cell delivery and im...
Vieira, Sílvia; Strymecka, Paulina; Stanaszek, Luiza; Silva-Correia, Joana; Drela, Katarzyna; Fiedorowicz, Michał; Malysz-Cymborska, IzabelaThis work aims to engineer a new stable injectable Mn-based methacrylated gellan gum (Mn/GG-MA) hydrogel for real-time monitored cell delivery into the central nervous system. To enable the hydrogel visualization under Magnetic Resonance Imaging (MRI), GG-MA solutions were supplemented with paramagnetic Mn2+ ions before its ionic crosslink with artificial cerebrospinal fluid (aCSF). The resulting formulations w...
Manganese-labeled alginate hydrogels for image-guided cell transplantation
Araszkiewicz, A. M.; Oliveira, Maria Eduarda Moreira Pinheiro Santos; Svendsen, Terje; Drela, Katarzyna; Rogujski, Piotr; Malysz-Cymborska, I.Cell transplantation has been studied extensively as a therapeutic strategy for neurological disorders. However, to date, its effectiveness remains unsatisfactory due to low precision and efficacy of cell delivery; poor survival of transplanted cells; and inadequate monitoring of their fate in vivo. Fortunately, different bio-scaffolds have been proposed as cell carriers to improve the accuracy of cell delivery...