2 documents found, page 1 of 1
A study of the mechanism of the release of ATP from rat cortical astroglial cel...
Queiroz, G; Meyer, DK; Meyer, A; Starke, K; von Kugelgen, IGlutamate and the selective agonists at ionotropic glutamate receptors N-methyl-D-aspartate, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) and kainate release ATP from superfused primary cultures of rat cortical astrocytes. The mechanism of this release was investigated. The release of ATP elicited by N-methyl-D-aspartate and kainate was abolished or greatly reduced in the absence of external calc...
Release of ATP from cultured rat astrocytes elicited by glutamate receptor acti...
Queiroz, G; GebickeHaerter, PJ; Schobert, A; Starke, K; VonKugelgen, IThe release of ATP was studied in cultures of astrocytes derived from the brain hemispheres of newborn rats. There was a basal efflux of ATP, which was increased up to 19-fold by glutamate (300-1000 mu M), N-methyl-D-aspartate (20-500 mu M), alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA; 30-100 mu M) and kainate (20 mu M). The N-methyl-D-aspartate receptor-selective antagonist 2-amino-5-phosphonope...