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Study of hTERT and Histone 3 Mutations in Medulloblastoma
Pereira, Marta Sofia Carvalho Ribeiro Viana; Almeida, Gisele Caravina; Stavale, João Norberto; Malheiro, Susana; Clara, Carlos; Lobo, PatríciaHotspot activating mutations of the telomerase reverse transcriptase (hTERT) promoter region were recently described in several tumor types. These mutations lead to enhanced expression of telomerase, being responsible for telomere maintenance and allowing continuous cell division. Additionally, there are alternative telomere maintenance mechanisms, associated with histone H3 mutations, responsible for disruptin...
Malignant transformation of pleomorphic xanthoastrocytoma: Case report
Tella Júnior, Oswaldo Ignácio; Herculano, Marco Antonio; Prandini, Mirto Nelso; Stavale, João Norberto; Aguiar, Paulo HenriqueSubmitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:20:37Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:38:41Z : No. of bitstreams: 1 2-s2.0-0037353007.pdf: 242029 bytes, checksum: 477fa25452c4e95bc8aae712e6202529 (MD5); Made available in DSpace on 2014-05-27T11:20:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2003-03-01; We report a case of a pleomorphic xa...
Infecção pelo citomegalovírus em pacientes com síndrome da imunodeficiência adq...
Turchi, Marília Dalva; Pannuti, Claudio Sérgio; Sumita, Laura Masami; Vilas Boas, Lucy Santos; Weinberg, Adriana; Stavale, João NorbertoBetween April 1986 and June 1987, 50 patients meeting the CDC criteria for AIDS were studied for serological and virological evidence of CMV infection. Attempts for virus isolation from peripheral blood, urine and saliva were performed in cell culture lines of human foreskin fibroblasts and CMV specific IgG and IgM were assayed by IFI and IgG by ELISA. A total of 121 blood, 119 urine and 96 saliva samples were ...
Hepatic involvement in human brucellosis
Pignatari, Antonio Carlos Campos; Castelo Filho, Adauto; Stavale, João Norberto; Matas, Sandro Luiz de Andrade; Jamnik, Sergio; Kim, Su BongTwo cases of hepatic involvement in human brucellosis are presented with special reference to the diferencial diagnosis of granulomatous hepatites.; São relatados dois casos de brucelose humana apresentando comprometimento hepático, com especial referência ao diagnóstico diferencial das hepatites granulomatosas.