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Increasing the fungicidal action of Amphotericin B by inhibiting the Nitric Oxi...

Vriens,Kim; Kumar, Phalguni Tewari; Struyfs, Caroline; Cools, Tanne L.; Spincemaille, Pieter; Kokalj, Tadej; Marques, Belém Sampaio; Ludovico, Paula

Amphotericin B (AmB) induces oxidative and nitrosative stresses, characterized by production of reactive oxygen and nitrogen species, in fungi. Yet, how these toxic species contribute to AmB-induced fungal cell death is unclear. We investigated the role of superoxide and nitric oxide radicals in AmB's fungicidal activity in Saccharomyces cerevisiae, using a digital microfluidic platform, which enabled monitorin...

Date: 2017   |   Origin: RepositóriUM - Universidade do Minho
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