31 documents found, page 1 of 4
Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus
Sola, S; Garshelis, DL; Amaral, JD; Noyce, KV; Coy, PL; Steer, CJ; Iaizzo, PA; Rodrigues, CMPTo date, no other studies have examined the seasonal changes in circulating levels of various bile acids in the plasma of wild North American black bears, Ursus americanus. Using gas chromatography, bile acid concentrations were measured in plasma samples
Modulation of Hepatocyte Apoptosis
Solá, S; Amaral, JD; Aranha, MM; Steer, CJ; Rodrigues, CMP
Modulation of cell cycle proteins with a role on apoptosis of primary rat hepat...
Castro, REM; Kren, BT; Steer, CJ; Rodrigues, CMP
Nuclear steroid receptors modulate cellular trafficking of ursodeoxycholic acid...
Sola, S; Amaral, JD; Castro, RE; Ramalho, RM; Kren, BT; Steer, CJ; Rodrigues, CMP
Nuclear translocation of UDCA by the glucocorticoid receptor is required to red...
Sola, S; Amaral, J; Castro, RE; Ramalho, RM; Borralho, PM; Kren, BT; Tanaka, H; Steer, CJ; Rodrigues, CMPUrsodeoxycholic acid (UDCA) inhibits classical mitochondrial pathways of apoptosis by either directly stabiliz* mitochondrial membranes or modulating specific upstream targets. Furthermore, UDCA regulates apoptosis-related genes from transforming growth f
Ursodeoxycholic acid modulates cell cycle proteins that control apoptosis of pr...
Castro, RE; Amaral, JD; Kren, BT; Steer, CJ; Rodrigues, CMP
A distinct microarray gene expression profile in primary rat hepatocytes incuba...
Castro, RE; Sola, S; Ma, XM; Ramalho, RM; Kren, BT; Steer, CJ; Rodrigues, CMPBackground/Aims: Ursodeoxycholic acid (UDCA) and its taurine-conjugated derivative, TUDCA, modulate cell death and cell cycle regulators, such as E2F-1 and p53. However, precise pathways underlying UDCA's effects are not fully understood. The aim of this
Distinct gene expression profile associated with ursodeoxycholic acid treatment...
Castro, RE; Sola, S; Ramalho, RM; Kren, BT; Steer, CJ; Rodrigues, CM
p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3...
Fan, G; Ma, X; Wong, PY; Rodrigues, CMP; Steer, CJThe p53 tumor suppressor gene product plays an important role in the regulation of apoptosis. Transforming growth factor beta1 (TGF-beta1)-induced apoptosis in hepatic cells is associated with reduced expression of the retinoblastoma protein (pRb) and sub
Steroid nuclear receptors modulate the anti-apoptotic effects of ursodeoxycholi...
Sola, S; Castro, RE; Kren, BT; Steer, CJ; Rodrigues, CMP