16 documents found, page 1 of 2
Caspases and p53 Modulate FOXO3A/Id1 Signaling During Mouse Neural Stem Cell Di...
Aranha, Marcia M.; Sola, Susana; Low, Walter C.; Steer, Clifford J.; Rodrigues, Cecilia M. P.Neural stem cells (NSCs) differentiate into neurons and glia, and a large percentage undergoes apoptosis. The engagement and activity of apoptotic pathways may favor either cell death or differentiation. In addition, Akt represses differentiation by up-regulating the inhibitor of differentiation 1 (Id 1), through phosphorylation of its repressor FOXO3A. The aim of this study was to investigate the potential cro...
Role of Nuclear Steroid Receptors in Apoptosis
Amaral, Joana D.; Sola, Susana; Steer, Clifford J.; Rodrigues, Cecilia M. P.Nuclear steroid receptors (NSR) are ligand-activated transcription factors that play a key role in a variety of vital physiological phenomena including developmental or endocrine signaling, reproduction, and homeostasis. In addition, they are implicated in other important biological processes, such as apoptosis. Modulation of apoptosis by NSR is mostly associated with control of pro-apoptotic versus anti-apopto...
MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in H...
Borralho, Pedro M.; Kren, Betsy T.; Castro, Rui E.; da Silva, Isabel B. Moreira; Steer, Clifford J.; Rodrigues, Cecilia M. P.MicroRNAs are aberrantly expressed in cancer; microRNA-143 (miR-143) is down-regulated in colon cancer. HCT116 human colorectal cancer cells were used to investigate the biological role of miR-143. Transient miR-143 overexpression resulted in an approximate 60% reduction in cell viability. In addition, stable miR-143 overexpressing cells were selected with G418 and exposed to 5-fluorouracil. Increased stable ex...
Bile acids and apoptosis modulation
Ramalho, Rita M.; Viana, Ricardo J. S.; Low, Walter C.; Steer, Clifford J.; Rodrigues, Cecilia M. P.The potential role of apoptosis in Alzheimer's disease (AD) has been an area of intense research in recent years. Ursodeoxycholic acid (UDCA) and its taurine-conjugate, tauroursodeoxycholic acid (TUDCA) are endogenous bile acids that act as potent inhibitors of apoptosis. Their therapeutic effects have been tested in many experimental pathological conditions, including neurological disorders, such as AD. TUDCA ...
Apoptosis in Transgenic mice expressing the P301L mutated form of human tau
Ramalho, Rita M.; Viana, Ricardo J. S.; Castro, Rui E.; Steer, Clifford J.; Low, Walter C.; Rodrigues, Cecilia M. P.The rTg4510 mouse is a tauopathy model, characterized by massive neurodegeneration in Alzheimer's disease (AD)-relevant cortical and limbic structures, deficits in spatial reference memory, and progression of neurofibrillary tangles (NFT). In this study, we examined the role of apoptosis in neuronal loss and associated tau pathology. The results showed that DNA fragmentation and caspase-3 activation are common ...
Administration of thuroursodeoxycholic acid (TUDCA) reduces apoptosis following...
Rivard, Andrew L.; Steer, Clifford J.; Kren, Betsy T.; Rodrigues, Cecilia M. P.; Castro, Rui E.; Bianco, Richard W.; Low, Walter C.Black bear bile has been used in traditional Chinese medicine to treat liver and eye related illnesses for centuries. A major constituent of bile is ursodeoxycholic acid (UDCA). Recent analysis of the cellular effects of UDCA and its taurine conjugate tau
P53 is a specific molecular target of ursodeoxycholic acid in regulating apoptosis
Amaral, Joana D.; Castro, Rui E.; Sola, Susana; Steer, Clifford J.; Rodrigues, Cecilia Maria P.
Differential regulation of cyclin D1 and cell death by bile acids in primary ra...
Castro, Rui E.; Amaral, Joana D.; Sola, Susana; Kren, Betsy T.; Steer, Clifford J.; Rodrigues, Cecilia M. P.Ursodeoxycholic ( UDCA) and tauroursodeoxycholic ( TUDCA) acids modulate apoptosis and regulate cell- cycle effectors, including cyclin D1. In contrast, deoxycholic acid ( DCA) induces cell death and cyclin D1. In this study, we explored the role of cycli
Game and players
Sola, Susana; Aranha, Marcia M.; Steer, Clifford J.; Rodrigues, Cecilia M. P.Apoptosis represents a universal and exquisitely efficient cellular suicide pathway essential for a variety of normal biological processes ranging from embryonic development to ageing. In fact, tissue homeostasis is dependent on the perfect balance betwee
p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis
Amaral, Joana D.; Castro, Rui E.; Sola, Susana; Steer, Clifford J.; Rodrigues, Cecilia M. P.p53 plays an important role in regulating expression of genes that mediate cell cycle progression and/or apoptosis. In addition, we have previously shown that the hydrophilic bile acid ursodeoxycholic acid (UDCA) prevents transforming growth factor beta 1-induced p53 stabilization and apoptosis in primary rat hepatocytes. Therefore, we hypothesized that p53 may represent an important target in bile acid-induced...