11 documents found, page 1 of 2
Clinical and Epidemiological Features of Hospitalized and Ambulatory Patients w...
Caria, J; Pinto, R; Leal, E; Almeida, V; Cristóvão, G; Gonçalves, AC; Torres, M; Santos, MB; Pinheiro, H; Póvoas, D; Seixas, D; Lino, S; Cardoso, OMonkeypox, a neglected and re-emergent zoonotic disease caused by monkeypox virus (MPXV) infection, has been endemic in Central and Western Africa for decades. More recently, an outbreak has spread to a global level, occurring in sites with no previous reported cases and being clustered among men who have sex with men, suggesting new modes of transmission. There is an urgent need for research for a better under...
Oxidative stress profiles in brain point out a higher susceptibility of fish to...
Cardoso, O; Puga, S; Brandão, F; Canário, J; O'Driscoll, NJ; Santos, MA; Pacheco, M; Pereira, PThis study examines, for the first time, the neurotoxicity of Hg(II) and MeHg in fish (Diplodus sargus) in a time-course comparative perspective and considering realistic exposure levels and routes. Both forms followed an identical time-variation pattern of accumulation in the brain, but dietary MeHg was more efficiently transported to the brain. MeHg was substantially eliminated from the brain in 28 days of de...
Immunodeficiency and Autoimmunity Coming Together: a Nearly Missed Diagnosis
Carreiro, F; Betkova, S; Sepúlveda, C; Manata, MJ; Cardoso, O; Maltez, F; Moraes-Fontes, MFThe coexistence of human immunodeficiency virus (HIV) and systemic lupus erythematosus (SLE) appears to be unusual and the prevalence of patients who carry the dual diagnosis is currently unknown. We hereby present a case of a C4 deficient HIV-1 positive Caucasian female under highly active antiretroviral therapy for the past eight years, admitted to hospital with an aggressive and potentially fatal clinical pr...
Correlation of Helicobacter pylori genotypes with gastric histopathology in the...
Almeida, N; Donato, MM; Romãozinho, JM; Luxo, C; Cardoso, O; Cipriano, MA; Marinho, C; Fernandes, A; Sofia, CBACKGROUND: Outcome of Helicobacter pylori (H. pylori) infection results from interaction of multiple variables including host, environmental and bacterial-associated virulence factors. AIM: This study aimed to investigate the correlation of cagA, cagE, vacA, iceA and babA2 genotypes with gastric histopathology and disease phenotype in the central region of a South-European country. METHODS: This prospective st...
Beyond Maastricht IV: are standard empiric triple therapies for Helicobacter py...
Almeida, N; Donato, MM; Romãozinho, JM; Luxo, C; Cardoso, O; Cipriano, MA; Marinho, C; Fernandes, A; Calhau, C; Sofia, CBACKGROUND: Empiric triple treatments for Helicobacter pylori (H. pylori) are increasingly unsuccessful. We evaluated factors associated with failure of these treatments in the central region of Portugal. METHODS: This single-center, prospective study included 154 patients with positive (13)C-urea breath test (UBT). Patients with no previous H. pylori treatments (Group A, n = 103) received pantoprazole 40 mg 2×...
Triple Therapy with High-Dose Proton-Pump Inhibitor, Amoxicillin, and Doxycycli...
Almeida, N; Romãozinho, JM; Donato, MM; Luxo, C; Cardoso, O; Cipriano, MA; Marinho, C; Sofia, CINTRODUCTION: Helicobacter pylori resistance to antibiotics is steadily increasing and multidrug-resistant strains are common and difficult to eliminate, mainly in countries where bismuth, tetracycline, furazolidone, and rifabutin are unavailable. AIM: To evaluate the efficacy and safety of a triple therapy with proton-pump inhibitor (PPI), amoxicillin, and doxycycline in patients with multidrug-resistant H. py...
Metallo-beta-lactamase VIM-2 in clinical isolates of Pseudomonas aeruginosa fro...
Cardoso, O; Leitao, R; Figueiredo, A; Sousa, JC; Duarte, A; Peixe, LVResistance to carbapenems is emerging, and it is a great problem to therapeutics. Three isolates of Pseudomonas aeruginosa from a Portuguese hospital identified in urine and sputum, in 1995, presented a high-level resistance to imipenem (32 mg/L). Afterward, one isolate of P. aeruginosa recovered from urine of an ambulatory patient in 1998 showed high resistance to imipenem. and meropenem. The resistance to car...
Bacillary Angiomatosis by Bartonella Quintana in an HIV-Infected Patient
Santos, R; Cardoso, O; Rodrigues, P; Cardoso, J; Machado, J; Afonso, A; Bacellar, F; Marston, E; Proença, RBacillary angiomatosis and bacillary peliosis are opportunistic infections caused by Bartonella henselae and Bartonella quintana, which occur in patients with late-stage infection. We report a case of bacillary angiomatosis in an HIV-infected patient with skin, bone, and probably liver involvement, The identification of the agent (B quintana ) was done by polymerase chain reaction in the skin specimen. The pati...
The hemolytic-uremic syndrome.
Rodrigues, P A; Machado, J; Cardoso, O; Cruz, J; Carvalho, F; da Costa, M; Proença, RThe microangiopathic thrombotic syndromes--thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS)--are characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal dysfunction, fever and central nervous system abnormalities. Today they are considered as two extremes of a continuous spectrum named TTP--HUS. The syndrome is an uncommon disease with a high mortality rate, desp...
Síndrome Hemolítico-Urémico
Rodrigues, P; Machado, J; Cardoso, O; Cruz, J; Carvalho, F; Marques da Costa; Proença, ROs síndromes de mieroangiopatia trombótica - Púrpura Trombótica Trombocitopénica (PTT) e Síndrome Hemolftico Urémico (SHU) - são caracterizados por anemia hemolftica microan giopática, trombocitopénia, alterações da função renal, febre e anomalias do sistema nervoso central. Actualmente são considerados como dois extremos de um espectro contínuo designado PTT- SHU. São doenças raras com uma taxa de mortalidade ...