30 documents found, page 1 of 3
Medical cannabinoids for treatment of neuropsychiatric symptoms in dementia: a ...
Stella,Florindo; Valiengo,Leandro C. Lane; Paula,Vanessa J. R. de; Lima,Carlos Augusto de Mendonça; Forlenza,Orestes V.Abstract Introduction Neuropsychiatric symptoms are an integral component of the natural history of dementia, occurring from prodromal to advanced stages of the disease process and causing increased burden and morbidity. Clinical presentations are pleomorphic and clinical management often requires combinations of pharmacological and non-pharmacological interventions. However, limited efficacy and a non-negligib...
Early diagnosis and treatment of Alzheimer’s disease: new definitions and chall...
Pais,Marcos; Martinez,Luana; Ribeiro,Octávio; Loureiro,Júlia; Fernandez,Romel; Valiengo,Leandro; Canineu,Paulo; Stella,Florindo; Talib,LedaThe prevalence of Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is expected to more than double by 2050. Studies on the pathophysiology of AD have been changing our understanding of this disorder and setting a new scenario for drug development and other therapies. Concepts like the “amyloid cascade” and the “continuum of AD,” discussed in this article, are now well established. From update...
Increased CSF levels of total Tau in patients with subcortical cerebrovascular ...
Radanovic,Márcia; Stella,Florindo; Silva,Lis Gomes; Talib,Leda L.; Forlenza,Orestes V.ABSTRACT. Cognitive impairment includes mild cognitive decline and dementia, such as Alzheimer's disease (AD) and cerebrovascular-related pathologies. Objective: To investigate the profile of AD-related CSF biomarkers in a sample of cognitively impaired and unimpaired older adults with concomitant subcortical cerebrovascular burden. Methods: Seventy-eight older adults attending an outpatient psychogeriatric cli...
Cortical correlates of affective syndrome in dementia due to Alzheimer’s disease
Hayata,Thaís T.; Bergo,Felipe P. G.; Rezende,Thiago J.; Damasceno,Alfredo; Damasceno,Benito P.; Cendes,Fernando; Stella,Florindo; Balthazar,Marcio L. F.Neuropsychiatric symptoms in Alzheimer’s disease (AD) are prevalent, however their relationship with patterns of cortical atrophy is not fully known. Objectives To compare cortical atrophy’s patterns between AD patients and healthy controls; to verify correlations between neuropsychiatric syndromes and cortical atrophy. Method 33 AD patients were examined by Neuropsychiatric Inventory (NPI). Patients and 29 con...
Visual conditions and postural directions affect postural sway variability in p...
Rinaldi,Natalia Madalena; Barbieri,Fabio Augusto; Teixeira-Arroyo,Claudia; Stella,Florindo; Gobbi,Lilian Teresa BuckenPostural sway variability was evaluated in Parkinsons disease (PD) patients at different stages of disease. Twenty PD patients were grouped into two groups (unilateral, 14; bilateral, 6) according to disease severity. The results showed no significant differences in postural sway variability between the groups (p >= 0.05). Postural sway variability was higher in the antero-posterior direction and with the e...
Effects of physical exercise on articular range of motion of the lower limb in ...
Barbieri,Fabio Augusto; Batistela,Rosangela Alice; Rinaldi,Natália Madalena; Teixeira-Arroyo,Claudia; Stella,Florindo; Gobbi,Lilian Teresa BuckenThe aim of this study was to investigate the effect of eight months of a multimodal program of physical exercise on articular range of motion of the lower limb of patients with Parkinson disease (PD), considering gender and disease stage. Seventeen individuals with PD participated in this study. Participants were assessed before of multimodal program of the physical exercise and after four and eight months of p...
Dual task and postural control in Alzheimer's and Parkinson's disease
Andrade,Larissa Pires de; Rinaldi,Natália Madalena; Coelho,Flávia Gomes de Melo; Tanaka,Kátia; Stella,Florindo; Gobbi,Lilian Teresa BuckenPatients with neurodegenerative diseases are required to use cognitive resources while maintaining postural control. The aim of this study was to investigate the effects of a frontal cognitive task on postural control in patients with Alzheimer, Parkinson and controls. Thirty-eight participants were instructed to stand upright on a force platform in two experimental conditions: single and dual task. Participant...
Effects of Square-Stepping Exercise on balance and depressive symptoms in older...
Pereira,Jessica Rodrigues; Gobbi,Sebastião; Teixeira,Camila Vieira Ligo; Nascimento,Carla Manuela Crispim; Corazza,Danilla IcassattiThe aim of this study was analyze the effects of Square-Stepping Exercise (SSE) on depressive symptoms, balance and functional mobility in older adults. Participants were distributed into two groups: Trained Group (TG), who performed a 16-week intervention with SSE and Control Group (CG), who performed only evaluations. The Berg Balance Scale and Time Up and Go Test (TUG) constituted the evaluation protocol to ...
Assessment of neuropsychiatric symptoms in dementia: Toward improving accuracy
Stella,FlorindoABSTRACT The issue of this article concerned the discussion about tools frequently used tools for assessing neuropsychiatric symptoms of patients with dementia, particularly Alzheimer's disease. The aims were to discuss the main tools for evaluating behavioral disturbances, and particularly the accuracy of the Neuropsychiatric Inventory - Clinician Rating Scale (NPI-C). The clinical approach to and diagnosis of...
Mild cognitive impairment (part 1): clinical characteristics and predictors of ...
Forlenza,Orestes V.; Diniz,Breno S.; Stella,Florindo; Teixeira,Antonio L.; Gattaz,Wagner F.Objective: To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short- and long-term prognosis thereof. Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012. Based ...