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Rhinitis associated with asthma is distinct from rhinitis alone

Bousquet, J; Melén, E; Haahtela, T; Koppelman, G H; Togias, A; Valenta, R; Akdis, C A; Czarlewski, W; Rothenberg, M; Valiulis, A; Wickmann, M; Bonini, M

Asthma, rhinitis and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease", coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis...


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