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Pyrimido[5,4-d]pyrimidine-based compounds as a novel class of antitrypanosomal ...

Lopes, Andre; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Carvalho, M. Alice

Sleeping sickness and leishmaniasis are neglected tropical diseases that threaten millions of people. The currently available therapies present several limitations, including high toxicity, lack of efficacy, and emerging drug resistance, prompting a search for novel therapeutic agents. In this work, we designed, synthesized, and in vitro evaluated the activity of new pyrimido[5,4-d]pyrimidines against Trypanoso...


A residential energy management system with offline population-based optimization

Soares, João; Lezama, Fernando; Ramos, Sérgio; Vale, Zita; Lopes, Andre

Expectable improvements in battery technology and lower prices will certainly contribute to increase the interest in residential energy storage systems in the near future. The installment of photovoltaic panels and the use of energy storage systems will help to reduce power losses in distribution and transmission power grid and increase network availability, and consequently, to reduce the dependency on the use...


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