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Gestational Exercise Antagonises the Impact of Maternal High-Fat High-Sucrose D...

Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Oliveira, Paulo J.; Ascensão, António; Magalhães, José

Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are relevant modulators of the intrauterine environment, increasing the risk of liver metabolic alterations in mothers and offspring. In contrast, as a non-pharmacological approach against metabolic disorders, exercise is highly recommended in GDM treatment. We analysed whether gestational exercise (GE) protects mothers from diet-in...


Fit mothers for a healthy future: Breaking the intergenerational cycle of non-a...

Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Costa, Rui Carlos; Ascensão, António; Magalhães, José

SPECIAL ISSUE: 'FOIEGRAS-Bioenergetic Remodelling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease'.


Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early...

Beleza, Jorge; Stevanović-Silva, Jelena; Coxito, Pedro; Rocha, Hugo; Santos, Paulo; Ascensão, António; Ramon Torrella, Joan; Magalhães, José

Mothers' antenatal strategies to improve the intrauterine environment can positively decrease pregnancy-derived intercurrences. By challenging the mother-fetus unit, gestational exercise (GE) favorably modulates deleterious stimuli, such as high-fat, high-sucrose (HFHS) diet-induced adverse consequences for offspring. We aimed to analyze whether GE alters maternal HFHS-consumption effects on male offspring's ma...


Exercise performed during pregnancy positively modulates liver metabolism and p...

Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Rocha, Hugo; Gaspar, Tiago Bordeira; Gärtner, Fátima; Correia, Rossana; Fernandes, Rui

Gestational diabetes mellitus (GDM) is associated with a high-risk for metabolic complications in offspring. However, exercise is recognized as a non-pharmacological strategy against metabolic disorders and is recommended in GDM treatment. This study aimed to investigate whether gestational exercise (GE) could modulate maternal high-fat high-sucrose (HFHS) diet-related hepatic metabolic and mitochondrial outcom...


Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic f...

Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Pereira, Susana; Rocha, Hugo; Gaspar, Tiago Bordeira; Gärtner, Fátima; Correia, Rossana

Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development of metabol...


Building-up fit muscles for the future: Transgenerational programming of skelet...

Beleza, Jorge; Stevanović-Silva, Jelena; Coxito, Pedro; Costa, Rui Carlos; Ascensão, António; Torrella, Joan Ramon; Magalhães, José

'Special issue - In Utero and Early Life Programming of Aging and Disease'. Skeletal muscle (SM) adaptations to physical exercise (PE) have been extensively studied due, not only to the relevance of its in situ plasticity, but also to the SM endocrine-like effects in noncontractile tissues, such as brain, liver or adipocytes. Regular PE has been considered a pleiotropic nonpharmacological strategy to prevent an...


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