5 documents found, page 1 of 1
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocyto...
Rosado-Ramos, Rita; Poças, Gonçalo M.; Marques, Daniela; Foito, Alexandre; M Sevillano, David; Lopes-da-Silva, Mafalda; Gonçalves, Luís G.Parkinson's Disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide for which there are only symptomatic therapies. Small molecules able to target key pathological processes in PD have emerged as interesting options for modifying disease progression. We have previously shown that a (poly)phenol-enriched fraction (PEF) of Corema album L. leaf extract modulates central events in...
Assessing the intestinal permeability and anti-inflammatory potential of sesqui...
Matos, Melanie S.; Anastácio, José D.; Allwood, J. William; Carregosa, Diogo; Marques, Daniela; Sungurtas, Julie; McDougall, Gordon J.; Menezes, ReginaFunding: This research and the article processing cost were funded by EU Horizon 2020 research & innovation programme under grant agreement N. 760891 project CHIC. M.S.M. also acknowledges the financial support from Fundação para a Ciência e Tecnologia for her PhD scholarship (SFRD/BD/145551/2019).; Cichorium intybus L. has recently gained major attention due to large quantities of health-promoting compounds in...
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for...
Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Inês; Garcia, Gonçalo; Rosado-Ramos, Rita; Freitag, Sabine; Alexander, Colin JamesFunding: iNOVA4Health-UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged. This work was supported by Fundação para a Ciência e Tecnologia (IF/01097/2013 to C.N.S.), by The Scottish Government Rural and Environment Science and Analytical...
RNA-seq, de novo transcriptome assembly and flavonoid gene analysis in 13 wild ...
Thole, Vera; Bassard, Jean Etienne; Ramírez-González, Ricardo; Trick, Martin; Ghasemi Afshar, Bijan; Breitel, Dario; Hill, Lionel; Foito, AlexandreThis research was funded by the European Union Framework Program 7, Project BacHBerry [FP7–613793]. The authors also acknowledge support from the Institute Strategic Programmes ‘Designing Future Wheat’ (BB/P016855/1), ‘Understanding and Exploiting Plant and Microbial Secondary Metabolism’ (BB/J004596/1) and ‘Molecules from Nature’ (BB/P012523/1) from the UK Biotechnology and Biological Sciences Research Council...
(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulati...
Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; Tomás-Barberán, Francisco A.We acknowledge Rita Ramos for support with qRT-PCR and Regina Menezes for the selection of primers; Antonio Temudo and Ana M. Nascimento for imaging support; The IMM-JLA Flow Cytometry Facility. We also thank Prof. Kuninori Suzuki (Tokyo Institute of Technology, Yokohama, Japan) for the 2xmCherry-ATG8 plasmid. TFO is supported by the DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain. Thi...