3 documents found, page 1 of 1
Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Th...
Gonçalves Neto,Geraldo S.; Costa,Romário P. da; Zanini,Camila L.; Aguiar,Anna Caroline C.; Souza,Juliana O. de; Souza,Guilherme E. deQualea grandiflora Mart. (“pau-terra”) is a medicinal plant symbolic from Cerrado biome. Qualea species reportedly have antiparasitic properties, but their active compounds have yet to be identified. In this study, we investigated the antiplasmodial activity of Q. grandiflora fruit and stem extracts against Plasmodium falciparum. The polar extracts of both fruits and stems showed promising in vitro antiplasmodi...
NEW DEGRADED QUINONE DITERPENOID FROM THE STEMS OF Byrsonima coccolobifolia Kun...
Sousa,Lorena R. F. de; Santos,Marcos H. F.; Severino,Vanessa G. P.; Severino,Richele P.; Vieira,Paulo C.A chemical investigation of two specimens of Byrsonima coccolobifolia collected in the southeast cerrado and from central Brazil was performed. A new degraded diterpenoid, byrsonimaquinone, was isolated from the stems along with known compounds. This is the first study on the roots of B. coccolobifolia, and several triterpenes, such as α-amyrin, β-amyrin, oleanolic acid, and glochidonol, along with a mixture of...
Leishmanicidal galloylquinic acids are noncompetitive inhibitors of arginase
Sousa,Lorena R. F. de; Ramalho,Suelem D.; Fernandes,João B.; Silva,Maria Fátima das G. F. da; Iemma,Mônica R. da C.; Corrêa,Caroindes J.Leishmanicidal galloylquinic acids were isolated from the ethyl acetate extract of Byrsonima coccolobifolia. These phenols and gallic acid showed to be a new class of potent noncompetitive inhibitors of arginase ARG (Ki ranging from 0.10 to 0.68 µmol L-1) from Leishmania amazonensis. Quinic acid did not exhibit significant inhibition of ARG, indicating that galloyl moiety has important features that allows the ...