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Results and experiences on effect biomarkers in HBM4EU and PARC occupational st...
Aimonen, Kukka; Silva, Maria João; Viegas, Susana; Scheepers, P.; Louro, Henriqueta; Martins, Carla; Duca, R.C.; Santonen, T.; HBM4EUTable of content: -Selection criteria for biomarkers of effect in PARC (PARC – WP4: Roadmap Linking HBM and Health; Biomarkers of effect in HBM4EU and PARC Occupational studies); - Lessons learned (Considerations; Advantages; Challenges; Success stories from HBM4EU); - Validation and Regulatory integration.
HBM4EU chromates study: overall results and recommendations for the biomonitori...
Santonen, Tiina; Porras, Simo P.; Bocca, Beatrice; Bousoumah, Radia; Duca, Radu Corneliu; Galea, Karen S.; Godderis, Lode; Göen, Thomas; Hardy, EmilieExposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating, and other surface treatment processes. The aim of this study was to provide EU-relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposur...
HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers...
Tavares, Ana; Aimonen, Kukka; Ndaw, Sophie; Fučić, Aleksandra; Catalán, Julia; Duca, Radu Corneliu; Godderis, Lode; Gomes, Bruno C.; Janasik, BeataA study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2′-deoxyguanosine in urine. Workers from several Cr(VI)-related industria...
HBM4EU chromates study: usefulness of measurement of blood chromium levels in t...
Ndaw, Sophie; Leso, Veruscka; Bousoumah, Radia; Rémy, Aurélie; Bocca, Beatrice; Duca, Radu Corneliu; Godderis, Lode; Hardy, Emilie; Janasik, BeataOccupational exposures to hexavalent chromium (Cr(VI)) can occur in welding, hot working stainless steel processing, chrome plating, spray painting, and coating activities. Recently, within the human biomonitoring for Europe initiative (HBM4EU), a study was performed to assess the suitability of different biomarkers to assess the exposure to Cr(VI) in various job tasks. Blood-based biomarkers may prove useful w...
Caracterização de biomarcadores de genotoxicidade em trabalhadores expostos a c...
Tavares, Ana; Aimonen, Kukka; Ndaw, Sophie; Fučić, Aleksandra; Catalán, Julia; Duca, Radu Corneliu; Godderis, Lode; Gomes, Bruno C.; Janasik, BeataNo âmbito da Iniciativa Europeia em Biomonitorização Humana (HBM4EU) realizou-se um estudo ocupacional, envolvendo trabalhadores com potencial exposição a crómio hexavalente [Cr( VI)], um reconhecido agente carcinogénico. No presente estudo são apresentados os resultados de biomarcadores de genotoxicidade, incluindo a análise de lesão no DNA e de alterações cromossómicas em células sanguíneas. O estudo foi real...
HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Worker...
Tavares, Ana; Aimonen, Kukka; Ndaw, Sophie; Fučić, Aleksandra; Catalán, Julia; Duca, Radu Corneliu; Godderis, Lode; Gomes, Bruno C.; Janasik, BeataA study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2'-deoxyguanosine in urine. Workers from several Cr(VI)-related industria...
HBM4EU chromates study - Overall results and recommendations for the biomonitor...
Santonen, Tiina; Porras, Simo P.; Bocca, Beatrice; Bousoumah, Radia; Duca, Radu Corneliu; Galea, Karen S.; Godderis, Lode; Göen, Thomas; Hardy, EmilieExposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure...