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Bioactive potential of Tripleurospermum inodorum with detailed insight into ant...

Ivanov, Marija; Aleksandrov, Aleksandra Popov; Božunović, Jelena; Dias, Maria Inês; Calhelha, Ricardo C.; Kulaš, Jelena; Barros, Lillian

This study evaluated Tripleurospermum inodorum extract for cytotoxic, anti-inflammatory, antioxidant, antimicrobial, and antibiofilm properties, alongside its phenolic profile, predicted pharmacological interactions and in vivo anti-inflammatory properties. The methanolic extract of T. inodorum was rich in apigenin derivatives, including apigenin-O-pentoside (5.234 mg/g) and apigenin-O-acetyl hexoside (4.929 mg...

Date: 2025   |   Origin: Biblioteca Digital do IPB

Valorization of Waste from Bell Pepper: Chemical Composition and Bioactive Pote...

Baessa, Jozias; Liberal, Ângela; Finimundy, Tiane C.; Stojković, Dejan; Mišić, Danijela; Pires, Tânia C.S.P.; Barros, Lillian; Fernandes, Ângela

Agri-food waste, especially in the fruit and vegetable sector, presents environmental and economic challenges. The bell pepper industry generates significant waste, offering potential for resource recovery within a circular economy. This study analyzed the nutritional and biochemical composition of waste from green, orange, and red bell peppers (Capsicum annuum L.) and evaluated the bioactive potential of hydro...

Date: 2025   |   Origin: Biblioteca Digital do IPB

Molecular diversity of bioactive compounds from horned melon peel: Solvent dyna...

Rajaković, Mladen; Gašić, Uroš; Bukvički, Danka; Pešić, Mirjana; Milinčić, Danijel; Petrović, Jovana; Sofrenić, Ivana; Shiraishi, Carlos S.H.

This study examines chemical composition and the antibacterial properties of various hydro-ethanolic extracts of Cucumis metuliferus E. Mey peel against the multidrug-resistant pathogen Pseudomonas aeruginosa. Several parameters, including ethanol concentration, extraction time, and ultrasonic power, were used in the ultrasound-assisted extraction of C. metuliferus peel. UHPLC-QToF-MS analysis was used to explo...

Date: 2025   |   Origin: Biblioteca Digital do IPB

Exploring the potential of underrated yet versatile crop Lunaria annua L.: New ...

Petrović, Jovana; Almeida, Daiana; Fernandes, Ângela; Stojković, Dejan; Robajac, Dragana; Silveira, Tayse F. F. da; Barros, Lillian

Lunaria annua is an underexplored crop with promising potential for use in various industries: food, oil etc. It grows rapidly, has low maintenance and high resistance to pathogens, which makes it a promising crop for sustainable cultivation. Herein, we investigated nutritional value, phenolic profile, and bioactive properties of L. annua seeds collected in the wild. The results we obtained indicate that seeds ...

Date: 2025   |   Origin: Biblioteca Digital do IPB

How Does Domestic Cooking Affect the Biochemical Properties of Wild Edible Gree...

Liava, Vasiliki; Fernandes, Ângela; Reis, Filipa S.; Finimundy, Tiane C.; Mandim, Filipa; Pinela, José; Stojković, Dejan; Ferreira, Isabel C.F.R.

Wild edible greens are a key ingredient of the so-called Mediterranean diet and they are commonly used in various local dishes in their raw or processed form. Domestic processing of edible greens may affect their nutritional value and chemical profile. In this work, six wild species (e.g., Cichorium spinosum L. (S1); Centaurea raphanina subsp. mixta (DC.) Runemark (S2); Picris echioides (L.) Holub (S3); Urosper...

Date: 2024   |   Origin: Biblioteca Digital do IPB

Use of bio-waste of Ilex paraguariensis A. St. Hil. (Yerba mate) to obtain an e...

Menezes, Barbara de Sena Nunes; Caleja, Cristina; Calhelha, Ricardo C.; Pinela, José; Dias, Maria Inês; Stojković, Dejan; Soković, Marina

In this work, a comparison between the extracts of dehydrated yerba mate (Ilex paraguariensis) and bio-waste of yerba mate leaves from the Brazilian industry was made. The incorporation of the functional extract as a preservative/functional ingredient in a pastry product (pancakes) was tested. The individual profile of phenolic compounds was determined by HPLC-DAD-ESI/MS, and the bioactive potential was assesse...

Date: 2023   |   Origin: Biblioteca Digital do IPB

Thymus species from romanian spontaneous flora as promising source of phenolic ...

Babotă, Mihai; Frumuzachi, Oleg; Mafra, Isabel; Nicolescu, Alexandru; Dias, Maria Inês; Pinela, José; Barros, Lillian; Añibarro-Ortega, Mikel

Wild thyme aerial parts (Serpylli herba) are recognized as a valuable herbal product with antioxidant, anti-inflammatory, and antibacterial effects. Although pharmacopoeial regulations allow its collection exclusively from Thymus serpyllum, substitution with other species is frequent in current practice. This study analyzed the phenolic composition, antioxidant, and enzyme-inhibitory and antimicrobial activity ...

Date: 2023   |   Origin: Biblioteca Digital do IPB

Phlomis fruticosa l. exerts in vitro antineurodegenerative and antioxidant acti...

Stojković, Dejan; Drakulić, Danijela; Inês Dias, Maria; Zengin, Gokhan; Barros, Lillian; Ivanov, Marija; Gašić, Uroš; Rajčević, Nemanja

Despite the significant advances in drug development we are witnessing the inability of health systems to combat both neurodegenerative diseases and cancers, especially glioblastoma. Hence, natural products are comprehen-sively studied in order to provide novel therapeutic options. This study aimed to explore anti-neurodegenerative and anti-glioblastoma potential of extract of Phlomis fruticosa L. using in vitr...

Date: 2022   |   Origin: Biblioteca Digital do IPB

Pineapple by-products as a source of bioactive compounds with potential for ind...

Moreira, Bruna; Pereira, Eliana; Finimundy, Tiane C.; Pinela, José; Calhelha, Ricardo C.; Carocho, Márcio; Stojković, Dejan; Soković, Marina

Pineapple is a tropical fruit consumed fresh or processed into various food products. However, the peel and crown of this fruit are not industrially exploited, thus generating tons of by-products that represent an economic and environmental concern. In order to promote the upcycling of these by-products, this work aimed to characterize the phenolic profile of its hydroethanolic extracts obtained from pineapple ...

Date: 2022   |   Origin: Biblioteca Digital do IPB

Valorization of Juglans regia leaves as cosmeceutical ingredients: bioactivity ...

Besrour, Nermine; Oludemi, Taofiq; Mandim, Filipa; Pereira, Carla; Dias, Maria Inês; Soković, Marina; Stojković, Dejan; Ferreira, Olga

The cosmetic industry is constantly searching for bioactive ingredients, namely, those obtained from natural sources with environmentally friendly connotations and less toxic effects. A previous study of our research group optimized the extraction of phenolic compounds from Juglans regia by heat-assisted extraction. Due to its richness in different phenolic compounds, the present work aimed to develop a formula...

Date: 2022   |   Origin: Biblioteca Digital do IPB

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