2 documents found, page 1 of 1
First cultivation and characterization of mycobacterium ulcerans from the envir...
Portaels, Françoise; Meyers, Wayne M.; Ablordey, Anthony; Castro, António G.; Chemlal, Karim; Rijk, Pim de; Elsen, Pierre; Fissette, KristaBackground: Mycobacterium ulcerans disease, or Buruli ulcer (BU), is an indolent, necrotizing infection of skin, subcutaneous tissue and, occasionally, bones. It is the third most common human mycobacteriosis worldwide, after tuberculosis and leprosy. There is evidence that M. ulcerans is an environmental pathogen transmitted to humans from aquatic niches; however, well-characterized pure cultures of M. ulceran...
Evidence for an intramacrophage growth phase of Mycobacterium ulcerans
Torrado, Egídio; Fraga, Alexandra Gabriel; Castro, António G.; Stragier, Pieter; Meyers, Wayne M.; Portaels, Françoise; Silva, Manuel T.; Pedrosa, JorgeMycobacterium ulcerans is the etiologic agent of Buruli ulcer (BU), an emerging tropical skin disease. Virulent M. ulcerans secretes mycolactone, a cytotoxic exotoxin with a key pathogenic role. M. ulcerans in biopsy specimens has been described as an extracellular bacillus. In vitro assays have suggested a mycolactone-induced inhibition of M. ulcerans uptake by macrophages in which its proliferation has not be...