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Basilar Artery Occlusion Management: Specialist Perspectives From an Internatio...

Edwards, C; Drumm, B; Siegler, J; Schonewille, W; Klein, P; Huo, X; Chen, Y; Abdalkader, M; Qureshi, M; Strbian, D; Liu, X; Hu, W; Ji, X; Li, C

Background and purpose: Two early basilar artery occlusion (BAO) randomized controlled trials did not establish the superiority of endovascular thrombectomy (EVT) over medical management. While many providers continue to recommend EVT for acute BAO, perceptions of equipoise in randomizing patients with BAO to EVT versus medical management may differ between clinician specialties. Methods: We conducted an intern...


Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality

Nguyen, T; Qureshi, M; Klein, P; Yamagami, H; Abdalkader, M; Mikulik, R; Sathya, A; Mansour, O; Czlonkowska, A; Lo, H; Field, T; Charidimou, A

Background and purpose: Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year. Methods: We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries...


Endovascular Therapy Versus No Endovascular Therapy in Patients Receiving Best ...

Berberich, A; Finitsis, S; Strambo, D; Michel, P; Herweh, C; Meyer, L; Hanning, U; Strbian, D; Abdalkader, M; Nogueira, R; Puetz, V; Kaiser, D

Background and purpose: Endovascular therapy (EVT) is increasingly reported for treatment of isolated posterior cerebral artery (PCA) occlusions although its clinical benefit remains uncertain. This study-level meta-analysis investigated the functional outcomes and safety of EVT and best medical management (BMM) compared to BMM alone for treatment of PCA occlusion stroke. Methods: We conducted a literature sear...


Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

Nogueira, RG; Qureshi, MM; Abdalkader, M; Martins, SO; Yamagami, H; Qiu, Z; Mansour, OY; Sathya, A; Czlonkowska, A; Tsivgoulis, G; Aguiar de Sousa, D

Objective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified ...


Intravenous thrombolysis in acute ischemic stroke due to intracranial artery di...

Bernardo, F; Nannoni, S; Strambo, D; Bartolini, B; Michel, P; Sirimarco, G

Efficacy and safety of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) due to intracranial artery dissection (IAD) are currently not established. We aimed to present a single-center experience on IAD-related AIS treated by IVT. We selected all consecutive patients with IAD-related AIS treated by IVT from a prospectively constructed single-center acute stroke registry from 2003 to 2017. We reviewed...


Efficacy and safety of endovascular treatment in acute ischemic stroke due to c...

Bernardo, F; Nannoni, S; Strambo, D; Puccinelli, F; Saliou, G; Michel, P, et al.

BACKGROUND: Limited observational data are available on endovascular treatment in acute ischemic stroke due to cervical artery dissection. Three studies comparing endovascular treatment with standard medical therapy or intravenous thrombolysis in cervical artery dissection-related acute ischemic stroke did not demonstrate superiority of endovascular treatment. Efficacy and the choice of endovascular treatment t...


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