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Interpretation of chronic pain clinical trial outcomes : IMMPACT recommended co...

Smith, Shannon M.; Dworkin, Robert H.; Turk, Dennis C.; McDermott, Michael P.; Eccleston, Christopher; Farrar, John T.; Rowbotham, Michael C.

Interpreting randomized clinical trials (RCTs) is crucial to making decisions regarding the use of analgesic treatments in clinical practice. In this article, we report on an Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) consensus meeting organized by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks, the purpose...


Evaluation of minimally invasive, ultrasound-guided synovial biopsy techniques ...

Humby, Frances; Kelly, Stephen; Bugatti, Serena; Manzo, Antonio; Filer, Andrew; Mahto, Arti; Fonseca, João Eurico; Lauwerys, Bernard

Objective: Because limited data currently support the clinical utility of peripherally expressed biomarkers in guiding treatment decisions for patients with rheumatoid arthritis, the search has turned to the disease tissue. The strategic aim of the Outcome Measures in Rheumatology (OMERACT) synovitis working group over the years has been to develop novel diagnostic and prognostic synovial biomarkers. A critical...


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