3 documents found, page 1 of 1
Animal models of depression and drug delivery with food as an effective dosing ...
Costa-Nunes, Joaõ P.; Cline, Brandon H.; Araújo-Correia, Margarida; Valencą, Andreia; Markova, Natalyia; Dolgov, Oleg; Kubatiev, Aslan; Yeritsyan, NairaMultiple models of human neuropsychiatric pathologies have been generated during the last decades which frequently use chronic dosing. Unfortunately, some drug administration methods may result in undesirable effects creating analysis confounds hampering model validity and preclinical assay outcomes. Here, automated analysis of floating behaviour, a sign of a depressive-like state, revealed that mice, subjected...
Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM ...
Cline, Brandon H.; Costa-Nunes, Joao P.; Cespuglio, Raymond; Markova, Natalyia; Santos, Ana I.; Bukhman, Yury V.; Kubatiev, AslanPublisher Copyright: © 2015 Cline, Costa-Nunes, Cespuglio, Markova, Santos, Bukhman, Kubatiev, Steinbusch, Lesch and Strekalova.; Central insulin receptor-mediated signaling is attracting the growing attention of researchers because of rapidly accumulating evidence implicating it in the mechanisms of plasticity, stress response, and neuropsychiatric disorders including depression. Dicholine succinate (DS), a mi...
Hippocampal gene expression of deiodinases 2 and 3 and effects of 3,5-diiodo-L-...
Strekalova, TatyanaCentral thyroid hormone signaling is important in brain function/dysfunction, including affective disorders and depression. In contrast to 3,3',5-triiodo-L-thyronine (T3), the role of 3,5-diiodo-L-thyronine (T2), which until recently was considered an inactive metabolite of T3, has not been studied in these pathologies. However, both T3 and T2 stimulate mitochondrial respiration, a factor counteracting the path...