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Towards a consensus definition of allostatic load: a multi-cohort, multi-system...
McCrory, C; McLoughlin, S; Layte, R; NiCheallaigh, C; O'Halloran, AM; Barros, H; Berkman, LF; Bochud, M; Crimmins, EM; Farrell, MT; Fraga, S; Grundy, EBackground: Allostatic load (AL) is a multi-system composite index for quantifying physiological dysregulation caused by life course stressors. For over 30 years, an extensive body of research has drawn on the AL framework but has been hampered by the lack of a consistent definition.Methods: This study analyses data for 67,126 individuals aged 40-111 years participating in 13 different cohort studies and 40 bio...
Adverse Childhood Events and Health Biomarkers: A Systematic Review
Soares, S; Rocha, V; Kelly-Irving, M; Stringhini, S; Fraga, SBackground: This systematic review aimed to summarize evidence reporting epigenetic and/or neuro-immuno-endocrine embedding of adverse childhood events (ACEs) in children, with a particular focus on the short-term biological effect of those experiences. Methods: A search was conducted in PsycINFO®, PubMed®, Isi Web of Knowledge and Scopus, until July 2019, to identify papers reporting the short-term biological ...
Socioeconomic circumstances and lung function growth from early adolescence to ...
Rocha, V; Severo, M; Ramos, E; Falcão, H; Stringhini, S; Fraga, SBackground A reduced lung function in early adulthood is associated with respiratory and non-respiratory diseases and is a long-term predictor of mortality. This study investigated the association between early socioeconomic circumstances (SEC) and lung function growth trajectories from early adolescence until early adulthood. Methods We analysed data from the EPITeen population-based study, including adolescen...
Life-course socioeconomic disadvantage and lung function: a multicohort study o...
Rocha, V; Fraga, S; Moreira, C; Carmeli, C; Lenoir, A; Steptoe, A; Giles, G; Goldberg, M; Zins, M; Kivimäki, M; Vineis, P; Vollenweider, P; Barros, HBackground Lung function is an important predictor of health and a marker of physical functioning at older ages. This study aimed to quantify the years of lung function lost according to disadvantaged socioeconomic conditions across the life-course. Methods This multicohort study used harmonised individual-level data from six European cohorts with information on life-course socioeconomic disadvantage and lung f...
Life-course socioeconomic status and lung function in adulthood: a study in the...
Rocha, V; Stringhini, S; Henriques, A; Falcão, H; Barros, H; Fraga, SObjective This study aims to investigate the association of life-course socioeconomic status (SES) with lung function during adulthood, by exploring the influence of life-course social mobility and of cumulative exposure to low SES. Methods Participants were 1458 individuals from EPIPorto study, a population-based cohort of Portuguese adults. The life-course SES was computed using participants’ paternal occupat...
Special Report: The Biology of Inequalities in Health: The Lifepath Consortium
Vineis, P; Avendano-Pabon, M; Barros, H; Bartley, M; Carmeli, C; Carra, L; Chadeau-Hyam, M; Costa, G; Delpierre, C; D'Errico, A; Fraga, S; Giles, GFunded by the European Commission Horizon 2020 programme, the Lifepath research consortium aimed to investigate the effects of socioeconomic inequalities on the biology of healthy aging. The main research questions included the impact of inequalities on health, the role of behavioral and other risk factors, the underlying biological mechanisms, the efficacy of selected policies, and the general implications of ...
Childhood socioeconomic conditions are associated with increased chronic low-gr...
Fraga, S; Severo, M; Ramos, E; Kelly-Irving, M; Silva, S; Ribeiro, AI; Petrovic, D; Barros, H; Stringhini, SObjective Early life adversity has been associated with increased risk of inflammation and inflammation-related diseases in adulthood. This study aimed to examine the association of childhood socioeconomic conditions with chronic low-grade inflammation over adolescence. Methods We used information on 2942 members (1507 girls and 1435 boys) of the EPITeen (Epidemiological Health Investigation of Teenagers in Por...
The contribution of sleep to social inequalities in cardiovascular disorders: a...
Petrovic, D; Haba-Rubio, J; de Mestral, Vargas, C; Kelly-Irving, M; Vineis, P; Kivimäki, M; Nyberg, S; Gandini, M; Bochud, M; Vollenweider, PAims: Sleep disturbances exhibit a strong social patterning, and inadequate sleep has been associated with adverse health outcomes, including cardiovascular disorders (CVD). However, the contribution of sleep to socioeconomic inequalities in CVD is unclear. This study pools data from eight European cohorts to investigate the role of sleep duration in the association between life-course socioeconomic status (SES...
Neighbourhood socioeconomic deprivation and allostatic load: a multi-cohort study
Ribeiro, AI; Fraga, S; Kelly-Irving, M; Delpierre, C; Stringhini, S; Kivimaki, M; Joost, S; Guessous, I; Gandini, M; Vineis, P; Barros, HLiving in deprived neighbourhoods may have biological consequences, but few studies have assessed this empirically. We examined the association between neighbourhood deprivation and allostatic load, a biological marker of wear and tear, taking into account individual’s socioeconomic position. We analysed data from three cohort studies (CoLaus-Switzerland; EPIPorto-Portugal; Whitehall II-UK) comprising 16,364 pa...
Socioeconomic circumstances and respiratory function from childhood to early ad...
Rocha, V; Soares, S; Stringhini, S; Fraga, SObjective Disadvantaged socioeconomic circumstances in early life have the potential to impact lung function. Thus, this study aimed to summarise evidence on the association between socioeconomic circumstances and respiratory function from childhood to young adulthood. Design Systematic review and meta-analysis. Methods Following the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines, ...