18 documents found, page 1 of 2
Neuropsychiatric symptoms in brain diseases - historical foundations
Engelhardt,Eliasz; Sudo,Felipe Kenji; Alves,Gilberto Sousa; Laks,JersonABSTRACT. Neuropsychiatric symptoms, which may appear alone or combined with cognitive and neurological manifestations, are frequent in many brain dysfunctions or lesions due to vascular, traumatic, neurodegenerative, or systemic conditions. Throughout history, many of the most prominent names have contributed to the clinical definition of the currently recognized mental symptoms and syndromes. The present pape...
Neuropsychiatric symptoms and executive function impairments in Alzheimer’s dis...
Tiel,Chan; Sudo,Felipe Kenji; Calmon,Ana BeatrizABSTRACT Neuropsychiatric symptoms (NPS) in dementia are prevalent, under-recognized and little studied regarding their pathophysiological aspects. The pathophysiological mechanism, as well as the possible role of vascular lesions in the genesis of these symptoms, are still matters of debate. Objective: to describe and compare the prevalence and severity of NPS in subjects with Alzheimer's disease (AD) and vasc...
A panel of clinical and neuropathological features of cerebrovascular disease t...
Alves,Gilberto Sousa; Carvalho,Luiza de Amorim de; Sudo,Felipe Kenji; Briand,Lucas; Laks,Jerson; Engelhardt,EliaszABSTRACT. The last decade has witnessed substantial progress in acquiring diagnostic biomarkers for the diagnostic workup of cerebrovascular disease (CVD). Advanced neuroimaging methods not only provide a strategic contribution for the differential diagnosis of vascular dementia (VaD) and vascular cognitive impairment (VCI), but also help elucidate the pathophysiological mechanisms ultimately leading to small v...
A continuum of executive function deficits in early subcortical vascular cognit...
Sudo,Felipe Kenji; Amado,Patricia; Alves,Gilberto Sousa; Laks,Jerson; Engelhardt,EliaszABSTRACT. Background. Subcortical Vascular Cognitive Impairment (SVCI) is a clinical continuum of vascular-related cognitive impairment, including Vascular Mild Cognitive Impairment (VaMCI) and Vascular Dementia. Deficits in Executive Function (EF) are hallmarks of the disorder, but the best methods to assess this function have yet to be determined. The insidious and almost predictable course of SVCI and the mu...
Percheron thalamopeduncular syndrome with cervical dystonia: A case report
Vasconcellos,Luiz Felipe; Tiel,Chan; Sudo,Felipe Kenji; Moreira,Denise Madeira; Engelhardt,EliaszABSTRACT Bilateral thalamic infarctions are usually caused by occlusion of the "Artery of Percheron" (AoP). Thalamopeduncular syndrome is among the most common presentations of AoP occlusion. A 59-year-old male presented abrupt decreased level of consciousness. After several weeks, on regaining consciousness, he exhibited oculomotor abnormalities, ataxic gait, cervical dystonia, and cognitive and behavioral cha...
Neuropsychiatric symptoms in Vascular Cognitive Impairment: A systematic review
Tiel,Chan; Sudo,Felipe Kenji; Alves,Gilberto Sousa; Ericeira-Valente,Letice; Moreira,Denise Madeira; Laks,Jerson; Engelhardt,EliaszNeuropsychiatric symptoms or Behavioral and Psychological Symptoms of Dementia (BPSD) are common and invariably appear at some point during the course of the disease, mediated both by cerebrovascular disease and neurodegenerative processes. Few studies have compared the profiles of BPSD in Vascular Cognitive Impairment (VCI) of different subtypes (subcortical or cortical) and clinical stages (Vascular Cognitive...
Neuroimaging criteria and cognitive performance in vascular mild cognitive impa...
Sudo,Felipe Kenji; Alves,Gilberto Sousa; Tiel,Chan; Ericeira-Valente,Letice; Moreira,Denise Madeira; Laks,Jerson; Engelhardt,EliaszABSTRACT The recognition of Cerebrovascular Disease (CVD) at earlier clinical stages may favor the control of vascular risk factors and prevention of dementia. However, operational criteria for symptomatic phases at non-dementia stages are often difficult, as the current criteria normally require the evidence of extensive subcortical disease. OBJECTIVE To identify the neuroimaging profile of Vascular Mild Cogni...
Cadasil - genetic and ultrastructural diagnosis: case report
Silva,Julio Cesar Vasconcelos da; Chimelli,Leila; Sudo,Felipe Kenji; Engelhardt,EliaszABSTRACT Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary disorder which affects the cerebral vasculature due to mutations in the NOTCH 3 gene. The diagnosis may be established through genetic testing for detection of these mutations and/or by skin biopsy. We report a case of the disorder in a female patient, who presented recurrent transient i...
White matter hyperintensities, executive function and global cognitive performa...
Sudo,Felipe Kenji; Alves,Carlos Eduardo Oliveira; Alves,Gilberto Sousa; Ericeira-Valente,Letice; Tiel,Chan; Moreira,Denise Madeira; Laks,JersonVascular mild cognitive impairment (VaMCI) represents an early symptomatic stage of vascular cognitive impairment and might be associated to fronto-executive dysfunction.MethodsTwenty-six individuals (age: 73.11±7.90 years; 65.4% female; schooling: 9.84±3.61 years) were selected through neuropsychological assessment and neuroimaging. Clinical and neuroimaging data of VaMCI individuals (n=15) were compared to no...
Dysexecutive syndrome and cerebrovascular disease in non-amnestic mild cognitiv...
Sudo,Felipe Kenji; Alves,Carlos Eduardo Oliveira; Alves,Gilberto Sousa; Ericeira-Valente,Letice; Tiel,Chan; Moreira,Denise Madeira; Laks,JersonABSTRACT Objective: Non-amnestic dysexecutive Vascular Mild Cognitive Impairment (VaMCI) may represent preclinical Vascular Dementia (VaD). The aim of this study was to summarize the clinical, neuropsychological and neuroimaging aspects of VaMCI; and to assess its patterns of progression to dementia. Methods: Searches were made in the ISI Web of Knowledge, PubMed and Lilacs databases, using the terms "mild cogn...