9 documents found, page 1 of 1
Microcephaly measurement in adults and its association with clinical variables
Costa,Nicole Rezende da; Mancine,Livia; Salvini,Rogerio; Teixeira,Juliana de Melo; Rodriguez,Roberta Diehl; Leite,Renata Elaine ParaizoABSTRACT OBJECTIVE To establish a microcephaly cut-off size in adults using head circumference as an indirect measure of brain size, as well as to explore factors associated with microcephaly via data mining. METHODS In autopsy studies, head circumference was measured with an inelastic tape placed around the skull. Total brain volume was also directly measured. A linear regression was used to determine the asso...
The role of VES-13 to identify limited life expectancy in older adults in prima...
Assis,Danilo Lopes; Chagas,Virgínia Oliveira; Saulo,Helton; Suemoto,Claudia Kimie; Santana,Alfredo Nicodemos CruzABSTRACT Objective To investigate the potential role of the Vulnerable Elders Survey to identify older adults with limited life expectancy in primary healthcare settings. Method This cross-sectional study was performed in all (nine) healthcare units in Jatai, Goiás (Brazil) from July to December 2018. A sample size of 407 older adults was obtained considering an older population (≥ 60 years old). Participants a...
Hypertension is the underlying cause of death assessed at the autopsy of indivi...
Coelho,Juliana Chaves; Ferretti-Rebustini,Renata Eloah de Lucena; Suemoto,Claudia Kimie; Leite,Renata Elaine Paraizo; Jacob-Filho,WilsonABSTRACT Objective: To analyze hypertension and its relationship with the causes of death identified by the autopsy. Method: Cross-sectional study analyzed 356 participants belonging to the Brazilian Aging Brain Study Group, over 50 years of age, autopsied at the Sao Paulo Autopsy Service between 2004 to 2014. A clinical interview was conducted with the informant of the deceased. Hypertension was defined by rep...
Association between diabetes and causes of dementia: Evidence from a clinicopat...
Matioli,Maria Niures Pimentel dos Santos; Suemoto,Claudia Kimie; Rodriguez,Roberta Diehl; Farias,Daniela Souza; Silva,Magnólia Moreira daABSTRACT. Background: Diabetes mellitus is a risk factor for dementia, especially for vascular dementia (VaD), but there is no consensus on diabetes as a risk factor for Alzheimer's disease (AD) and other causes of dementia. Objective: To explore the association between diabetes and the neuropathological etiology of dementia in a large autopsy study. Methods: Data were collected from the participants of the Bra...
Factors associated with morphometric brain changes in cognitively normal aging
Ferretti-Rebustini,Renata Eloah de Lucena; Jacob-Filho,Wilson; Suemoto,Claudia Kimie; Farfel,José Marcelo; Leite,Renata Elaine ParaisoOBJECTIVE: Cognitive impairment is associated with reductions in brain weight and volume. The factors related to morphometric brain changes in cognitively normal aging remain unknown. We aimed to identify which clinical factors are associated with morphometric brain changes in cognitively normal aging. METHODS: A cross-sectional study of 414 subjects, ≥50 years old submitted to clinical assessment and brain aut...
Validity of the Katz Index to assess activities of daily living by informants i...
Ferretti-Rebustini,Renata Eloah de Lucena; Balbinotti,Marcos Alencar Abaide; Jacob-Filho,Wilson; Rebustini,Flávio; Suemoto,Claudia KimieAbstract OBJECTIVE To analyze the evidences of construct validity of the Katz Index for the retrospective assessment of activities of daily living (ADL) by informants, to assist neuropathological studies in the elderly. METHOD A cross-sectional study analyzed the functional ability of ADL measure by the Katz Index, of 650 cases randomly selected from the Brazilian Brain Bank of the Ageing Brain Study Group (BBB...
Post-Mortem diagnosis of dementia by informant interview
Ferretti,Renata Eloah de Lucena; Damin,Antonio Eduardo; Brucki,Sonia Maria Dozzi; Morillo,Lilian Schafirovits; Perroco,Tibor Rilho; Campora,FláviaAbstract The diagnosis of normal cognition or dementia in the Brazilian Brain Bank of the Aging Brain Study Group (BBBABSG) has relied on postmortem interview with an informant. Objectives: To ascertain the sensitivity and specificity of postmortem diagnosis based on informant interview compared against the diagnosis established at a memory clinic. Methods: A prospective study was conducted at the BBBABSG and a...
Morphometric brain changes during aging: Results from a Brazilian necropsy sample
Ferretti,Renata Eloah de Lucena; Jacob-Filho,Wilson; Grinberg,Lea Tenenholz; Leite,Renata Elaine Paraízo; Farfel,José Marcelo; Suemoto,Claudia KimieAbstract The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods: A cross-sectional study was conducted at the São Paulo Autopsy Service in Brazil where, after informed consent, data was gathered from next of kin interview with reference to clinical status prior to death. Brain ...
Association between cardiovascular disease and dementia
Suemoto,Claudia Kimie; Ferretti,Renata Eloah; Grinberg,Lea Tenenholz; Oliveira,Kátia Cristina de; Farfel,José Marcelo; Leite,Renata Elaine ParaizoAbstract Longitudinal studies have shown association between cardiovascular risk factors and dementia. However, these studies are not capable of detecting asymptomatic cardiovascular alterations and thus may provide erroneous estimates of association. Autopsy studies could be more useful in elucidating these questions. The present clinicopathological study sought to examine the relationship between dementia, ca...