This work was supported by the Swiss National Science Foundation (grants 310030_188888, CRSII5_177163, IZRJZ3_164171 and IZLSZ3_170834) and the European Research Council (309540?EVODRTB and 883582-ECOEVODRTB); Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology. Basel, Switzerland / University of Basel. Basel, Switzerland.; Swiss Tropical and Public Health Instit...
Ancient sublineage of the Mycobacterium tuberculosis Beijing genotype is endemic and prevalent in East Asia and rare in other world regions. While these strains are mainly drug susceptible, we recently identified a novel clonal group Beijing 1071-32 within this sublineage emerging in Siberia, Russia and present in other Russian regions. This cluster included only multi/extensive drug resistant (MDR/XDR) isolate...
Made available in DSpace on 2018-11-26T17:20:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01. Added 1 bitstream(s) on 2019-10-09T18:26:33Z : No. of bitstreams: 1 S0074-02762017000300182.pdf: 270918 bytes, checksum: 1d42f1b3f1ff91f1be67429b10053eb9 (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); BACKGROUND Tuberculosis (TB) continues to be a disease that affects many countri...
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, sugges...