6 documents found, page 1 of 1
Astrocyte-derived TNF and glutamate critically modulate microglia activation by...
Canedo, T; Portugal, CC; Socodato, R; Almeida, TO; Terceiro, AF; Bravo, J; Silva, AI; Magalhães, JD; Guerra-Gomes, S; Oliveira, JF; Sousa, NMethamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational purposes. Besides disrupting the monoaminergic system and promoting oxidative brain damage, Meth also causes neuroinflammation, contributing to synaptic dysfunction and behavioral deficits. Aberrant activation of microglia, the largest myeloid cell population in the brain, is a common feature in neurological disorders tri...
Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss...
Socodato, R; Henriques, JF; Portugal, CC; Almeida, TO; Tedim-Moreira, J; Alves, RL; Canedo, T; Silva, C; Magalhães, A; Summavielle, T; Relvas, JBAlcohol abuse adversely affects the lives of millions of people worldwide. Deficits in synaptic transmission and in microglial function are commonly found in human alcohol abusers and in animal models of alcohol intoxication. Here, we found that a protocol simulating chronic binge drinking in male mice resulted in aberrant synaptic pruning and substantial loss of excitatory synapses in the prefrontal cortex, wh...
Early-life stress affects drug abuse susceptibility in adolescent rat model ind...
Alves, RL; Oliveira, P; Lopes, IM; Portugal, CC; Alves, CJ; Barbosa, F; Summavielle, T; Magalhães, AThe development of substance abuse problems occurs due to a diverse combination of risk factors. Among these risks, studies have reported depression and early-life stress as of importance. These two factors often occur simultaneously, however, there is a lack of understanding of how their combined effect may impact vulnerability to drug abuse in adolescence. The present study used rats with different vulnerabil...
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology a...
Socodato, R; Portugal, CC; Canedo, T; Rodrigues, A; Almeida, TO; Henriques, JF; Vaz, SH; Magalhães, J; Silva, CM; Baptista, FI; Alves, RLNervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of ß-amyloid plaques, and memory ...
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signal...
Bras, JP; Bravo, J; Freitas, J; Barbosa, MA; Santos, SG; Summavielle, T; Almeida, MIGrowing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders. In some pathological conditions, microglia produce increased levels of cytotoxic and inflammatory mediators, such as tumor necrosis factor alpha (TNF-a), which can reactivate microglia in a positive feedback mechanism....
A mouse model reproducing the pathophysiology of neonatal group B streptococcal...
Andrade, EB; Magalhães, A; Puga, A; Costa, M; Bravo, J; Portugal, CC; Ribeiro, A; Correia-Neves, M; Faustino, A; Firon, A; Trieu-Cuot, P; Summavielle, TGroup B streptococcal (GBS) meningitis remains a devastating disease. The absence of an animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective treatments. We describe here a mouse model in which bacteria are transmitted to the offspring from vaginally colonised pregnant females, the natural route of infection. ...