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Rationale and Methodological Approach Underlying the Development of the Sequent...

Moreno, Rui; Rhodes, Andrew; Ranzani, Otavio; Salluh, Jorge; Berger-Estilita, Joana; Coopersmith, Craig M.; Juffermans, Nicole P.; Laffey, John

Importance: The Sequential Organ Failure Assessment (SOFA) score was published in 1996 to describe organ dysfunction in critically ill adult patients in a readily quantifiable and sequential manner. Considerable changes have occurred over the last 3 decades in the use of organ support drugs and devices and in patient outcomes, necessitating revision of the score. Objectives: To develop definitions of organ dysf...


The Sequential Organ Failure Assessment (SOFA) Score

Moreno, Rui; Rhodes, Andrew; Piquilloud, Lise; Hernandez, Glenn; Takala, Jukka; Gershengorn, Hayley B.; Tavares, Miguel; Coopersmith, Craig M.

Funding Information: RM has no competing interest to declare relevant to this article. AR has no competing interest to declare relevant to this article. LP has no competing interest to declare relevant to this article. GH has no competing interest to declare relevant to this article. JT has no competing interest to declare relevant to this article. HBG received funding from Gilead Sciences, Inc. to serve on COV...


COVID-19 symptoms at hospital admission vary with age and sex

Abdukahil, Sheryl Ann; Abe, Ryuzo; Abel, Laurent; Absil, Lara; Acker, Andrew; Adachi, Shingo; Adam, Elisabeth; Adriao, Diana; Ainscough, Kate

Funding This work was supported by the Department for International Development and Wellcome Trust [215091/Z/18/Z]; the Bill and Melinda Gates Foundation [OPP1209135]. Country-specifc support was provided by the Canadian Institutes of Health Research Coronavirus Rapid Research Funding Opportunity [OV2170359]; the Health Research Board Ireland [CTN Award 2014-012]; National Institute for Health Research (NIHR) [...


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