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Physical activity, sedentary behaviour, and childhood asthma: a European collab...

Eijkemans, M; Mommers, M; Harskamp-van Ginkel, MW; Vrijkotte, TGM; Ludvigsson, J; Faresjö, Å; Bergström, A; Ekström, S; Grote, V; Koletzko, B

OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined. SETTING: Ch...


Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysi...

Robinson, L; Roccaldo, R; Rodrigues, D; Rodriguez Perez, MdC; Rodríguez Villamizar, LA; Rodríguez, AY; Roggenbuck, U; Rohloff, P; Rohner, F

Background: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods: We used data from 3663 population-based studies with 222 million participants that...


Rhinitis Associated with Asthma is Distinct from Rhinitis Alone: The ARIA‐MeDAL...

Bousquet, J; Melén, E; Haahtela, T; Koppelman, GH; Togias, A; Valenta, R; Akdis, CA; Czarlewski, W; Rothenberg, M; Valiulis, A; Wickman, M; Akdis, M

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...


Exposure to natural environments during pregnancy and birth outcomes in 11 euro...

Torres Toda, M; Avraam, D; James Cadman, T; Fossati, S; de Castro, M; Dedele, A; Donovan, G; Elhakeem, A; Estarlich, M; Fernandes, A; Gonçalves, R

Research suggests that maternal exposure to natural environments (i.e., green and blue spaces) promotes healthy fetal growth. However, the available evidence is heterogeneous across regions, with very few studies on the effects of blue spaces. This study evaluated associations between maternal exposure to natural environments and birth outcomes in 11 birth cohorts across nine European countries. This study, par...


Early-life respiratory tract infections and the risk of school-age lower lung f...

van Meel, ER; Mensink-Bout, SM; den Dekker, HT; Ahluwalia, TS; Annesi-Maesano, I; Arshad, SH; Baïz, N; Barros, H; von Berg, A; Bisgaard, H

Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods We used individual participant data of 150 090 children primarily from the EU Child ...


Height and body-mass index trajectories of school-aged children and adolescents...

Horimoto, AR; Hormiga, CM; Horta, BL; Houti, L; Howitt, C; Htay, TT; Htet, AS; Htike, MMT; Hu, Y; Huerta, JM; Huhtaniemi, IT; Huidumac Petrescu, C

Background: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods: For this pooled analysis, we used a database of cardiometabolic risk factors colla...


Changes in parental smoking during pregnancy and risks of adverse birth outcome...

Philips, EM; Santos, S; Trasande, L; Aurrekoetxea, JJ; Barros, H; von Berg, A; Bergström, A; Bird, PK; Brescianini, S; Ní Chaoimh, C; Charles, MA

Background. Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, spec...


Erratum to: Scaling up strategies of the chronic respiratory disease programme ...

Bousquet, J; Farrell, J; Crooks, G; Hellings, P; Bel, E H; Bewick, M; Chavannes, N H; de Sousa, J Correia; Cruz, A A; Haahtela, T; Joos, G; Khaltaev, N

[This corrects the article DOI: 10.1186/s13601-016-0116-9.].


Fish and seafood consumption during pregnancy and the risk of asthma and allerg...

Stratakis, N; Roumeliotaki, T; Oken, E; Ballester, F; Barros, H; Basterrechea, M; Cordier, S; de Groot, R; den Dekker, HT; Duijts, L; Eggesbø, M

Background: It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis...


Mode of Delivery and Asthma at School Age in 9 European Birth Cohorts

Rusconi, F; Zugna, D; Annesi-Maesano, I; Baïz, N; Barros, H; Correia, S; Duijts, L; Forastiere, F; Inskip, H; Kelleher, CC; Larsen, PS; Mommers, M

Evidence on the association between mode of delivery and asthma at school age is inconclusive. We assessed the associations between specific modes of delivery and asthma in children from 9 European birth cohorts that enrolled participants between 1996 and 2006. Cohort-specific crude and adjusted risk ratios for asthma at ages 5–9 years were calculated using Poisson regression models and pooled. A sensitivity an...


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