7 documents found, page 1 of 1
Alkaline phosphatase dual-binding sites for collagen dictate cell migration and...
Susana Guerreiro; Unger, RE; Cerqueira, NMFSA; Sartoris, A; Martins, MJ; Barbosa, MA; Soares, R; Granja, PL; Kirkpatrick, CJInteractions between cell types, growth factors, and extracellular matrix components involved in angiogenesis are crucial for new vessel formation leading to tissue regeneration. This study investigated whether cocultures of fibroblasts and endothelial cells (ECs; from macro- or microvasculature) play a role in the formation of microvessel-like structures by ECs, as well as modulate fibroblast differentiation a...
COVID-19 in relation to hyperglycemia and diabetes mellitus
Hayder M. Al-kuraishy; Ali I. Al-Gareeb; M. Alblihed; Susana Guerreiro; Natália Cruz-Martins; Gaber El-Saber BatihaCoronavirus disease 2019 (COVID-19), triggered by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), may lead to extrapulmonary manifestations like diabetes mellitus (DM) and hyperglycemia, both predicting a poor prognosis and an increased risk of death. SARS-CoV-2 infects the pancreas through angiotensin-converting enzyme 2 (ACE2), where it is highly expressed compared to other organs, leading t...
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A System...
Soares, S; Susana Guerreiro; Cruz Martins, N; Faria, I; Baylina, P; Sales, MG; Correa Duarte, MA; Fernandes, RIn the last years, extensive investigation on miRNomics have shown to have great advantages in cancer personalized medicine regarding diagnosis, treatment and even clinical outcomes. Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. Here, we aim to provide an overview on the mechanisms of miRNA ...
Tackling endothelium remodeling in cardiovascular disease
Guašová, Z; Susana Guerreiro; Link, R; Soares, R; Tomeková, VEndothelial dysfunction is considered an early marker of atherosclerosis. Herein, we address the molecular mechanisms affecting endothelium remodeling in disease. Vascular calcification is highly prevalent in patients with ischemic cardiovascular disease, cerebrovascular disorder, and renal failure, being a common feature in aging, diabetes, dyslipidemia, abnormal valve biomechanics, end-stage renal disease and...
Mesenchymal Stem Cells (MSCs) as a Potential Therapeutic Strategy in COVID-19 P...
Coelho, A; Alvites, RD; Branquinho, MV; Susana Guerreiro; Mauricio, ACIn 2019, an outbreak of an unknown coronavirus - SARS-CoV-2 - responsible for COVID-19 disease, was first reported in China, and evolved into a pandemic of huge dimensions and raised serious concerns for global health. The number of critical cases continues to increase dramatically, while vaccines and specific treatments are not yet available. There are several strategies currently being studied for the treatme...
Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: ...
Oliveira, S; Costa, J; Faria, I; Susana Guerreiro; Fernandes, RBackground and objectives: The incidence of cutaneous melanoma has been increasing. Melanoma is an aggressive form of skin cancer irresponsive to radiation and chemotherapy, rendering this cancer a disease with poor prognosis: In order to surpass some of the limitations addressed to melanoma treatment, alternatives like vitamins have been investigated. In the present study, we address this relationship and inve...
Kaempferol: A Key Emphasis to Its Anticancer Potential
Imran, M; Salehi, B; Sharifi Rad, J; Gondal, TA; Saeed, F; Imran, A; Shahbaz, M; Fokou, PVT; Arshad, MU; Khan, H; Susana Guerreiro; Martins, NA marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective effect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, c...