10 documents found, page 1 of 1
Exploring marine resources against neurological disorders: the neuroprotective ...
Silva, Joana; Alves, Celso; Susano, Patrícia; Martins, Alice; Pinteus, Susete; Gaspar, Helena; Alfonso, Amparo; Pedrosa, RuiOxidative stress is strongly involved in the pathogenesis of neurodegenerative diseases, like Parkinson´s disease (PD). Particularly, an excess of reactive oxygen species (ROS) released by the cells promotes an oxidative stress condition, which is a main cause of tissue injury leading to nervous system dysfunction. In this work, the antioxidant, neuroprotective and antiinflammatory activities of different fract...
Seaweed’s role in energetic transition: From environmental pollution challenges...
Pinteus, Susete; Susano, Patrícia; Alves, Celso; Silva, Joana; Martins, Alice; Pedrosa, RuiResulting from the growing human population and the long dependency on fossil-based energies, the planet is facing a critical rise in global temperature, which is affecting all ecosystem networks. With a growing consciousness this issue, the EU has defined several strategies towards environment sustainability, where biodiversity restoration and preservation, pollution reduction, circular economy, and energetic ...
Saccorhiza polyschides: A source of natural active ingredients for greener skin...
Susano, Patrícia; Silva, Joana; Alves, Celso; Martins, Alice; Pinteus, Susete; Gaspar, Helena; Goettert, Márcia Inês; Pedrosa, RuiThe growing knowledge about the harmful effects caused by some synthetic ingredients present in skincare products has led to an extensive search for natural bioactives. Thus, this study aimed to investigate the dermatological potential of five fractions (F1–F5), obtained by a sequential extraction procedure, from the brown seaweed Saccorhiza polyschides. The antioxidant (DPPH, FRAP, ORAC and TPC), anti-enzymati...
Mitigating the negative impacts of marine invasive species – Sargassum muticum ...
Susano, Patrícia; Silva, Joana; Alves, Celso; Martins, Alice; Pinteus, Susete; Gaspar, Helena; Goettert, Márcia Inês; Pedrosa, RuiSargassum muticum is a highly invasive species, threatening marine biodiversity worldwide. One strategy to reduce marine invaders’ impacts is to promote their use as valuable biomass for new products development. On the other hand, there is a rising conscience of natural compounds importance as health promoters. The present work was designed to sustainably use the marine invasive seaweed S. muticum collected of...
The therapeutic potential of naturally occurring peptides in counteracting SH-S...
Perlikowska, Renata; Silva, Joana; Alves, Celso; Susano, Patrícia; Pedrosa, RuiPeptides have revealed a large range of biological activities with high selectivity and efficiency for the development of new drugs, including neuroprotective agents. Therefore, this work investigates the neuroprotective properties of naturally occurring peptides, endomorphin-1 (EM-1), endomorphin-2 (EM-2), rubiscolin-5 (R-5), and rubiscolin-6 (R-6). We aimed at answering the question of whether wellknown opioi...
Loliolide, a new therapeutic option for neurological diseases? In vitro neuropr...
Silva, Joana; Alves, Celso; Martins, Alice; Susano, Patrícia; Simões, Marco; Guedes, Miguel; Rehfeldt, Stephanie; Pinteus, Susete; Gaspar, HelenaParkinsons Disease (PD) is the second most common neurodegenerative disease worldwide, and is characterized by a progressive degeneration of dopaminergic neurons. Without an effective treatment, it is crucial to find new therapeutic options to fight the neurodegenerative process, which may arise from marine resources. Accordingly, the goal of the present work was to evaluate the ability of the monoterpenoid lac...
Unravelling the anti-Inflammatory and antioxidant potential of the marine spong...
Gaspar, Helena; Silva, Joana; Alves, Celso; Martins, Alice; Teodoro, Fernando; Susano, Patrícia; Pinteus, Susete; Pedrosa, Rui; Alves, JoanaInflammation is a double-edged sword, as it can have both protective effects and harmful consequences, which, combined with oxidative stress (OS), can lead to the development of deathly chronic inflammatory conditions. Over the years, research has evidenced the potential of marine sponges as a source of effective anti-inflammatory therapeutic agents. Within this framework, the purpose of this study was to evalu...
Marine endophytic fungi associated with Halopteris scoparia (Linnaeus) Sauvagea...
Calado, Maria da Luz; Silva, Joana; Alves, Celso; Susano, Patrícia; Santos, Débora; Alves, Joana; Martins, Alice; Gaspar, Helena; Pedrosa, RuiMarine fungi and, particularly, endophytic species have been recognised as one of the most prolific sources of structurally new and diverse bioactive secondary metabolites with multiple biotechnological applications. Despite the increasing number of bioprospecting studies, very few have already evaluated the cosmeceutical potential of marine fungal compounds. Thus, this study focused on a frequent seaweed in th...
Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: n...
Silva, Joana; Alves, Celso; Pinteus, Susete; Susano, Patrícia; Simões, Marco; Guedes, Miguel; Martins, Alice; Rehfeldt, Stephanie; Gaspar, HelenaThe treatment of Parkinson´s disease (PD) has benefited from significant advances resulting from the increasing research efforts focused on new therapeutics. However, the current treatments for PD are mostly symptomatic, alleviating disease symptoms without reversing or retarding disease progression. Thus, it is critical to find new molecules that can result in more effective treatments. Within this framework, ...
Unravelling the dermatological potential of the brown seaweed Carpomitra costata
Susano, Patrícia; Silva, Joana; Alves, Celso; Martins, Alice; Gaspar, Helena; Pinteus, Susete; Mouga, Teresa; Goettert, Márcia Ines; Petrovski, ZeljkoThe ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-en...