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Mycobacterium tuberculosis strains are differentially recognized by TLRs with a...

Carmona, J. A.; Cruz, Andrea; Teixeira, Lucia de Fatima Moreira; Sousa, Carole Lara Veiga de; Sousa, Jeremy Nicolas Carvalho; Osório, Nuno S.

Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb lineages and prone to elicit non-protective immune responses. However, highly heterogeneous immune responses were reported upon infection of innate immune cells with Bj strains or stimulation with their glycolipids. Using both in vitro and...


Epidemiology of Mycobacterium bovis infection in wild boar (Sus scrofa) from Po...

Santos, Nuno; Neves, Margarida Correia; Ghebremichael, Solomon; Källenius, Gunilla; Svenson, Stefan; Almeida, Virgílio

Tuberculosis has been diagnosed in wild boar (Sus scrofa) in several European countries during the last decade; however, almost no information has been reported to date for Portugal. This study aimed to investigate tuberculosis in wild boar in Portugal through characterization of Mycobacterium bovis infection and identification of disease risk factors. Tissue samples were obtained from hunted wild boar during t...


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