7 documents found, page 1 of 1
Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Mole...
Sharifi-Rad, J; Martins, N; López-Jornet, P; Lopez, EPF; Harun, N; Yeskaliyeva, B; Beyatli, A; Sytar, O; Shaheen, S; Sharopov, F; Taheri, Y; Docea, AOCoumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensi...
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
Sharifi-Rad, J; Quispe, C; Patra, JK; Singh, YD; Panda, MK; Das, G; Adetunji, CO; Michael, OS; Sytar, O; Polito, L; Živkovic, J; Martins, NPaclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and brea...
Chitosan nanoparticles as a promising tool in nanomedicine with particular emph...
Sharifi-Rad, J; Quispe, C; Butnariu, M; Rotariu, LS; Sytar, O; Sestito, S; Rapposelli, S; Akram, M; Iqbal, M; Krishna, A; Kumar, NVA; Braga, SSThe study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding ...
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
Sharifi-Rad, J; Quispe, C; Mukazhanova, Z; Knut, E; Turgumbayeva, A; Kipchakbayeva, A; Seitimova, G; Mahomoodally, MF; Lobine, D; Koay, A; Wang, JResveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effec...
Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Dis...
Quispe, C; Martins, N; Manca, ML; Manconi, M; Sytar, O; Hudz, N; Shanaida, M; Kumar, M; Taheri, Y; Martorell, M; Sharifi-Rad, J; Pintus, G; Cho, WCDue to its vast therapeutic potential, the plant-derived polyphenol curcumin is utilized in an ever-growing number of health-related applications. Here, we report the extraction methodologies, therapeutic properties, advantages and disadvantages linked to curcumin employment, and the new strategies addressed to improve its effectiveness by employing advanced nanocarriers. The emerging nanotechnology application...
Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health
Salehi, B; Machin, L; Monzote, L; Sharifi-Rad, J; Ezzat, SM; Salem, MA; Merghany, RM; El Mahdy, NM; Klllç, CS; Sytar, O; Sharifi-Rad, M; Sharopov, FQuercetin (Que) and its derivatives are naturally occurring phytochemicals with promising bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer's, antiarthritic, cardiovascular, and wound-healing effects of Que have been extensively investigated, as well as its anticancer activity against different cancer cell lines has been recently reported. Que and its derivatives...
Myricetin bioactive effects: Moving from preclinical evidence to potential clin...
Taheri, Y; Suleria, HAR; Martins, N; Sytar, O; Beyatli, A; Yeskaliyeva, B; Seitimova, G; Salehi, B; Semwal, P; Painuli, S; Kumar, A; Azzini, ESeveral flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the neuroprotective activity, showing preclinical activities on Alzheimer, Parkinson, and Huntington diseases, and even in amyotrophic lateral sclerosis. Also, myricet...