4 documents found, page 1 of 1
Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and ...
Martino, A.; Campa, D.; Buda, G.; Sainz, J.; GarcIa Sanz, R.; Jamroziak, K.; Reis, R. M.; Weinhold, N.; Jurado, M.; Rıos, R.; Szemraj-Rogucka, ZofiaMultiple myeloma (MM) is a hematological neoplasm that arises from a single clone of malignant plasma cells in the bone marrow. In Europe, 4.6/100 000 males and 3.2/100 000 females every year develop MM, with a median age at diagnosis around 60 years.
Comprehensive investigation of genetic variation in the 8q24 region and multipl...
Reis, R. M.; Campa, Danielr; Martino, Alessandro; Sainz, Juan; Buda, Gabriele; Jamroziak, Krzysztof; Weinhold, Niels; García-Sanz, Ramón; Jurado, ManuelGenome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 c...
Impact of polymorphic variation at 7p15.3, 3p22.1 and 2p23.3 loci on risk of mu...
Reis, R. M.; Martino, Alessandro; Campa, Daniele; Jamroziak, Krzysztof; Sainz, Juan; Buda, Gabriele; García-Sanz, Ramón; Lesueur, Fabienne
Genetics and molecular epidemiology of multiple myeloma : the rationale for the...
Martino, Alessandro; Sainz, Juan; Buda, Gabriele; Jamroziak, Krzysztof; Reis, R. M.; García-Sanz, Ramón; Jurado, Manuel; Ríos, RafaelThere is strong evidence suggesting the presence of a genetic component in the aetiology of multiple myeloma (MM). However no genetic risk factors have been unequivocally established so far. To further our understanding of the genetic determinants of MM risk, a promising strategy is to collect a large set of patients in a consortium, as successfully done for other cancers. In this article, we review the main fi...