5 documents found, page 1 of 1
Interleukin-4 and Atopic Dermatitis
T, Torres; Mendes-Bastos, Pedro; Cruz, Maria J.; Duarte, Bruno; Filipe, Paulo; Lopes, Maria J.P.; Gonçalo, MargaridaPublisher Copyright: © The Author(s) 2025.; Atopic dermatitis (AD) is a common chronic inflammatory skin condition that significantly impairs patients’ quality of life as a result of intense itching and persistent eczematous lesions. Although AD has a multifaceted etiology—including genetic predisposition, environmental triggers, barrier dysfunction, and dysregulated immune responses—interleukin-4 (IL-4) has a ...
Abordagem do Doente com Psoríase pela Medicina Geral e Familiar: Algoritmo de R...
T, Torres; Henrique, Martinha; Oliveira, Hugo; Rodrigues, Madalena; Ferreira, Paulo; Morais, Paulo; Alves, Sérgio; Lopes, Tiago Castro; Cernadas, RuiIntroduction: The implementation of models capable of improving referral quality, limiting the growth of waiting lists in hospitals, and ensuring the best possible treatment and follow-up of the psoriatic patient is of the utmost importance. Material and methods: A panel of Family Physicians and Dermatologists discussed and created a simple and effective algorithm of referral for patients with psoriasis. Result...
Freeze-Dried Softisan® 649-Based Lipid Nanoparticles for Enhanced Skin Delivery...
Silva, Maria Inês; Barbosa, Ana Isabel; Costa Lima, Sofia A.; Costa, Paulo; T, Torres; Reis, SaletteInflammatory skin diseases, including psoriasis and atopic dermatitis, affect around one quarter to one third of the world population. Systemic cyclosporine A, an immunosuppressant agent, is included in the current therapeutic armamentarium of these diseases. Despite being highly effective, it is associated with several side effects, and its topical administration is limited by its high molecular weight and poo...
Diagnosis, Screening and Treatment of Patients with Palmoplantar Pustulosis (PP...
Freitas, Egídio; Rodrigues, Maria Alexandra; T, TorresPalmoplantar pustulosis (PPP) is a rare, chronic, recurrent inflammatory disease that affects the palms and/or the soles with sterile, erupting pustules, which are debilitating and usually resistant to treatment. It has genetic, histopathologic and clinical features that are not present in psoriasis; thus, it can be classified as a variant of psoriasis or as a separate entity. Smoking and upper respiratory infe...
Ustekinumab in Real-Life Practice: Experience in 116 Patients with Moderate-To-...
Raposo, I.; Bettencourt, A.; Leite, L.; Selores, M.; T, TorresUstekinumab is a monoclonal antibody directed against the p40 subunit common to both IL-12 and IL-23 cytokines. Although the evidence of ustekinumab efficacy and safety in clinical trials is extensively recognized, data on its use in clinical practice is limited. Our objective is to report on the real-life experience of two Portuguese dermatology departments with ustekinumab in patients with moderate to severe ...