18 documents found, page 1 of 2
Genetic determinants for prediction of outcome of patients with papillary thyro...
Póvoa, AA; Teixeira, E; Bella-cueto, MR; Batista, R; Pestana, A; Melo, M; Alves, T; Pinto, M; Sobrinho-Simões, M; Maciel, J; Soares, PPapillary thyroid carcinoma (PTC) usually presents an excellent prognosis, but some patients present with aggressive metastatic disease. BRAF, RAS, and TERT promoter (TERTp) genes are altered in PTC, and their impact on patient outcomes remains controversial. We aimed to determine the role of genetic alterations in PTC patient outcomes (recurrent/persistent disease, structural disease, and disease-specific mort...
Digital pathology workflow implementation at ipatimup
Eloy, C; Vale, J; Curado, M; Polónia, A; Campelos, S; Caramelo, A; Sousa, R; Sobrinho-Simões, MThe advantages of the digital methodology are well known. In this paper, we provide a detailed description of the process for the digital transformation of the pathology laboratory at IPATIMUP, the major modifications that operate throughout the processing pipeline, and the advantages of its implementation. The model of digital workflow implementation at IPATIMUP demonstrates that careful planning and adoption ...
Comprehensive assessment of tert mRNA expression across a large cohort of benig...
Pestana, A; Batista, R; Celestino, R; Canberk, S; Sobrinho-Simões, M; Soares, PThe presence of TERT promoter (TERTp) mutations in thyroid cancer have been associated with worse prognosis features, whereas the extent and meaning of the expression and activation of TERT in thyroid tumours is still largely unknown. We analysed frozen samples from a series of benign and malignant thyroid tumours, displaying non-aggressive features and low mutational burden in order to evaluate the presence of...
Clinicopathological features as prognostic predictors of poor outcome in papill...
Póvoa, AA; Teixeira, E; Bella-Cueto, MR; Melo, M; Oliveira, MJ; Sobrinho-Simões, M; Maciel, J; Soares, PPapillary thyroid cancer (PTC) has an indolent nature and usually excellent prognosis. Some PTC clinicopathological features may contribute to the development of aggressive metastatic disease. In this work, we want to evaluate PTC clinicopathological features that are presurgical prognostic predictors of patients’ outcomes and find which indicators are more adequate for tailoring surgical procedures and follow-...
Molecular aspects of thyroid calcification
Ferreira, LB; Gimba, E; Vinagre, J; Sobrinho-Simões, M; Soares, PIn thyroid cancer, calcification is mainly present in classical papillary thyroid carcinoma (PTC) and in medullary thyroid carcinoma (MTC), despite being described in benign lesions and in other subtypes of thyroid carcinomas. Thyroid calcifications are classified according to their diameter and location. At ultrasonography, microcalcifications appear as hyperechoic spots = 1 mm in diameter and can be named as ...
Telomere maintenance mechanisms in cancer
Gaspar, TB; Sá, A; Lopes, JM; Sobrinho-Simões, M; Soares, P; Vinagre, JTumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-independent alternative lengthening of telomeres (ALT) mechanism. In the last years, a great amount of data was gen...
CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and ...
Celestino, R; Nome, T; Pestana, A; Hoff, A; Gonçalves, AP; Pereira, L; Cavadas, B; Eloy, C; Bjøro, T; Sobrinho-Simões, M; Skotheim, R; Soares, PThe prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. Methods: We used high-throughput paired-end RNA sequencing technology to study four cases of FTC with different degree of capsular inva...
Dynamin-related protein 1 at the crossroads of cancer
Lima, AR; Santos, L; Correia, M; Soares, P; Sobrinho-Simões, M; Melo, M; Máximo, VMitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involve mitochondrial dynamics (fission and fusion), which occur in normal cells as well as in cells ...
NIS expression in thyroid tumors, relation with prognosis clinicopathological a...
Tavares, C; Coelho, MJ; Eloy, C; Melo, M; Rocha, AG; Pestana, A; Batista, R; Ferreira, LB; Rios, E; Selmi-Ruby, S; Cavadas, B; Pereira, LThyroid cancer therapy is based on surgery followed by radioiodine treatment. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane. We aimed to evaluate if NIS expression in thyroid primary tumors would be helpful in predicting tumor behavior, response to therapy and prognosis. NIS ...
OPNa overexpression is associated with matrix calcification in thyroid cancer c...
Ferreira, LB; Lima, RT; Bastos, A; Silva, AM; Tavares, C; Pestana, A; Rios, E; Eloy, C; Sobrinho-Simões, M; Gimba, E; Soares, POsteopontin (OPN) spliced variants (OPN-SV: OPNa, OPNb, and OPNc) are aberrantly expressed in tumors and frequently associated with cancer progression. This holds true for papillary thyroid carcinoma (PTC), which is the most common type of thyroid cancer (TC). PTC often presents with desmoplasia and dystrophic calcification, including psammoma bodies (PB). This work aimed to investigate total OPN (tOPN) and OPN...