4 documents found, page 1 of 1
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is a...
Xavier-Magalhães, Ana; Gonçalves, Céline S; Fogli, Anne; Lourenço, Tatiana; Pojo, Marta; Pereira, Bruno; Rocha, Miguel; Lopes, Maria CelesteThe lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR w...
Prognostic stratification of adult primary glioblastoma multiforme patients bas...
González-Tablas, María; Crespo, Inês; Vital, Ana Luísa; Otero, Álvaro; Nieto, Ana Belén; Sousa, Pablo; Patino-Alonso, María CarmenSeveral classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be easily implemented in routine diagnostics, and potentially impro...
Amplified and Homozygously Deleted Genes in Glioblastoma: Impact on Gene Expres...
Crespo, Inês; Tão, Hermínio; Nieto, Ana Belen; Rebelo, Olinda; Domingues, Patrícia; Vital, Ana Luísa; Patino, Maria del Carmen; Barbosa, MarcosBackground: Glioblastoma multiforme (GBM) displays multiple amplicons and homozygous deletions that involve relevant pathogenic genes and other genes whose role remains unknown. Methodology: Single-nucleotide polymorphism (SNP)-arrays were used to determine the frequency of recurrent amplicons and homozygous deletions in GBM (n = 46), and to evaluate the impact of copy number alterations (CNA) on mRNA levels of...
Analysis of allelic imbalances and protein expression in human high-grade astro...
Vital, Ana L.; Cruz, M. Teresa; Crespo, Inês; Dolores Tabernero, M.; Rebelo, Olinda; Tão, Hermínio; Gomes, Fernando; Orfão, Alberto; Lopes, M.Celeste