13 documents found, page 1 of 2
Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics
Silva, Francisco; Paulo, António; Pallier, Agnès; Même, Sandra; Tóth, Éva; Gano, Lurdes; Marques, Fernanda; Geraldes, Carlos F. G. C.Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNP...
Amide conjugates of the DO3A-N-(alpha-amino)propionate ligand: leads for stable...
Ferreira, Miguel Filipe Moreira Marques; Martins, André F.; Martins, Catarina I. O.; Ferreira, Paula M. T.; Tóth, Éva; Rodrigues, Tiago B.A novel synthetic methodology for preparing amide conjugates of the DO3A-N-(alfa-amino)propionate chelator is described, using the synthesis of the DO3A-N-(alfa-benzoylamido)propionate chelator as an illustrative example. The model Gd(DO3A-N-(alfa-benzoylamido)propionate) chelate displays accelerated water exchange, stability in a wide pH range and inertness towards transmetallation by Zn2+. The Gd(DO3A-N-(alaf...
Thermodynamic stability and relaxation studies of small, triaza-macrocylic Mn(I...
Sá, Arsénio Vasconcelos; Bonnet, Célia S.; Geraldes, Carlos F. G. C.; Tóth, Éva; Ferreira, Paula M. T.; André, João P.Due to its favorable relaxometric properties, Mn2+ is an appealing metal ion for magnetic resonance imaging (MRI) contrast agents. This paper reports the synthesis and characterization of three new triazadicarboxylate-type ligands and their Mn2+ chelates (NODAHep, 1,4,7-triazacyclononane-1,4-diacetate-7-heptanil; NODABA, 1,4,7-triazacyclononane-1,4-diacetate-7-benzoic acid; and NODAHA (1,4,7-triazacyclononane-1...
Mn(II) chelates with potential interest for MRI
Sá, Arsénio Vasconcelos; Bonnet, Célia S.; Geraldes, Carlos F. G. C.; Tóth, Éva; Ferreira, Paula M. T.; André, João P.
Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in ...
Torres, Suzana; Prata, Maria I. M.; Santos, Ana C.; André, João P.; Martins, José A.; Helm, Lothar; Tóth, Éva; García-Martín, Maria L.The recently reported amphiphilic chelate, [Gd(EPTPAC16)(H2O)]2-, forms supramolecular aggregates in aqueous solution by self-assembly of the monomers with a relaxometrically determined critical micellar concentration (CMC) of 0.34 mM. The effect of sonication on the aggregate size was characterized by dynamic light scattering and relaxometry, indicating the presence of premicellar aggregates and an overall dec...
H5EPTPACH2OH: Synthesis, Relaxometric Characterization and 1H NMR Spectroscopic...
Torres, Susana; Martins, José A.; André, João P.; Pereira, Giovannia A.; Kiraly, Robert; Brücher, Ernö; Helm, Lothar; Tóth, Éva; Geraldes, CarlosThe synthesis and characterization of a new metal chelator, 4-(S)-hydroxymethyl-3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid (H5EPTPACH2OH), is reported. Protonation constants for the ligand H5EPTPACH2OH and for the previously reported H5EPTPAC16 have been determined by potentiometry, which reveals that both ligands display slightly higher protonation constants relative to that of the ligand DTPA5-...
Supramolecular Assembly of an Amphiphilic GdIII Chelate: Tuning the Reorientati...
Torres, Susana; Martins, José A.; André, João P.; Geraldes, Carlos F. G. C.; Merbach, André E.; Tóth, ÉvaWe report the synthesis and characterization of the novel ligand H5EPTPA-C16 ((hydroxymethylhexadecanoyl ester)ethylenepropylenetriaminepentaacetic acid). This ligand was designed to chelate the GdIII ion in a kinetically and thermodynamically stable way while ensuring an increased water exchange rate (kex) on the GdIII complex owing to steric compression around the water-binding site. The attachment of a palmi...
Supramolecular assembly of an amphiphilic GdIII chelate: tuning the reorientati...
Torres, Susana; Martins, J. A. R.; André, João P.; Geraldes, Carlos F. G. C.; Merbach, André E.; Tóth, ÉvaIn this paper we report the synthesis and the characterization of the novel ligand H5EPTPA-C16 ((hydroxymethylhexadecanoyl ester)ethylenepropylenetriaminepentaacetic acid). This ligand was designed to chelate the GdIII ion in a kinetically and thermodynamically stable way while ensuring an increased water exchange rate (kex) on the GdIII complex due to steric compression around the water binding site. The attac...
Lanthanide(III) Chelates of DTPA Bis(amide) Glycoconjugates: Potential Imaging ...
Baía, Paula; André, João P.; Geraldes, Carlos F. G. C.; Martins, José A.; Merbach, André E.; Tóth, ÉvaThe synthesis and characterisation of a new class of DTPA bis(amide) linked glycoconjugates of different sugars [lactose (Lac) and galactose (Gal)] and valencies (di and tetra) and their LnIII complexes is reported. The 1H NMR spectra of the SmIII and EuIII complexes of DTPAGal2, DTPAGal4, and DTPALac2, obtained between 7 and 80 °C, indicate that several of the four possible diastereoisomeric pairs of structure...
Lanthanide(III) chelates of DTPA-bisamide glycoconjugates : potential imaging a...
Baía, Paula; André, João P.; Geraldes, Carlos F. G. C.; Martins, J. A. R.; Merbach, André E.; Tóth, ÉvaThe synthesis and characterization of a new class of DTPA bisamide-linked glycoconjugates of different sugars (lactose, Lac, and galactose, Gal) and valencies (di and tetra) and their Ln(III) complexes is reported. The 1H NMR spectra of the Sm(III) and Eu(III) complexes of DTPAGal2, DTPAGal4, and DTPALac2 obtained between 7 and 80 ºC, indicate that most (if not all) of the four possible diastereoisomeric pairs ...