4 documents found, page 1 of 1
New insights on Retinoic Acid Signaling-Metabolism interaction during lung bran...
Silva, Hugo Miguel FernandesA ramificação pulmonar é um processo complexo caracterizado por interações epitélio-mesênquima e coordenado por vias de sinalização que contribuem para a formação das vias respiratórias. A via de sinalização do Ácido Retinoico (AR) é crucial para o desenvolvimento pulmonar e é particularmente importante para o padrão próximo-distal e a ramificação pulmonar. Os mecanismos moleculares subjacentes aos estadios ini...
Developmental pathways underlying lung development and congenital lung disorders
Caldeira, Inês; Silva, Hugo Miguel Fernandes; Costa, Daniela Machado; Correia-Pinto, Jorge; Moura, Rute S.Lung organogenesis is a highly coordinated process governed by a network of conserved signaling pathways that ultimately control patterning, growth, and differentiation. This rigorously regulated developmental process culminates with the formation of a fully functional organ. Conversely, failure to correctly regulate this intricate series of events results in severe abnormalities that may compromise postnatal s...
Canonical sonic Hedgehog signaling in early lung development
Silva, Hugo Miguel Fernandes; Correia-Pinto, Jorge; Moura, Rute S.The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, it is able to trigger tissue-specific responses that, ultimately, contribute to the formation of a fully functional organism. Of all three HH proteins, Sonic ...
Metabolic biomarkers of chick embryonic lung development: impact of retinoic acid
Silva, Hugo Miguel FernandesPulmonary development is a complex process that depends on the activation of conserved signaling pathways that regulate cellular processes such as proliferation, differentiation and migration. Retinoic acid (RA) signaling is one of the active pathways during lung organogenesis, since it modulates branching morphogenesis in a dose-dependent manner. It is widely accepted that the cellular events underlying embryo...