3 documents found, page 1 of 1
Biological Applications of Macrocyclic Schiff Base Ligands and Their Metal Comp...
Golbedaghi, Reza; Tabanez, Andreia M.; Esmaeili, Somayeh; Lourenço, Rui FaustoThis article aims to provide a survey of biological applications of Schiff base macrocycles and their metal complexes, with emphasis given to the synthesis of the compounds and to their uses as antibacterial and antifungal agents. The literature on the subject, published during the 2005–2019 period, is shortly reviewed. This is an informed report collecting information on the addressed topic in a concise system...
Enhanced solid-state stability of amorphous ibrutinib formulations prepared by ...
Simões, Marta F.; Nogueira, Bernardo A.; Tabanez, Andreia M.; Rui Fausto; Pinto, Rui M. A.; Simões, SérgioOne of the applications of Hot-Melt Extrusion (HME) is the stabilization of amorphous drugs through its incorporation into polymeric blends in the form of Amorphous Solid Dispersions (ASDs). In this study, HME was applied to solve a real problem in the development of an ibrutinib product, stabilizing the amorphous form. A systematic approach was followed by combining theoretical calculations, high-throughput sc...
The crystal structure and Raman spectrum of the sodium salt of 5-Acetic acid hy...
Nogueira, Bernardo A.; Ildiz, Gulce O.; Tabanez, Andreia M.; Henriques, M. S. C.; Paixão, José A.; Fausto, RuiThe sodium salt of 5-acetic acid hydantoin (5AAH) was synthesized, and its crystal structure determined by single crystal X-ray diffraction. The material was found to exhibit rather unusual structural features. Firstly, contrarily to what is most common for hydantoins, the 5AAH molecules in the crystal bind the sodium ions through coordination via its oxygen atoms (instead of via a deprotonated ring nitrogen). ...