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Duas amplificações sequenciais por PCR para detecção de Schistosoma mansoni em ...
Espírito-Santo, Maria Cristina Carvalho do; Alvarado-Mora, Mónica Viviana; Pinto, Pedro Luiz Silva; Carrilho, Flair José; Pinho, João Renato RebelloA esquistossomose constitui grande problema de saúde pública, sendo que estimativas apontam para 200 milhões de pessoas infectadas no mundo e 700 milhões de pessoas em áreas de risco. No Brasil, existem áreas de alta, média e baixa endemicidade. Estudos demonstram que nas áreas endêmicas de baixa prevalência da infecção, a reduzida sensibilidade dos métodos parasitológicos torna-se evidente. Isto dificulta o di...
Dot-ELISA for the detection of IgM and IgG antibodies to Schistosoma mansoni wo...
Pinto, Pedro Luiz Silva; Kanamura, Herminia Y.; Silva, Rita Maria; Rossi, Cristina Renata Nardoto; Andrade Jr., Heitor Franco de; Amato Neto, VicenteHuman schistosomiasis, caused by Schistosoma mansoni, is highly prevalent in Brazil and usually diagnosed by time consuming stool analysis. Serological tests are of limited use in this disease, mainly for epidemiological studies, showing no discrimination between previous contact with the parasite and active infections. In the present study, we standardized and compared a Dot-ELISA for IgM and IgG antibodies ag...
Evaluation of the therapeutic activity of itraconazole in human and experimenta...
Moreira, Antonio Augusto Baillot; Souza, Hertha Barbara Wüllert Telles de; Amato Neto, Vicente; Matsubara, Luís; Pinto, Pedro Luiz SilvaAlguns pesquisadores demonstraram que o intraconzol, "in vitro" e na infecção aguda de animais, possui atividade antiparasitária referente ao Trypanosoma cruzi. Diante dessas observações, decidimos empreender estudo sobre e etapa crônica da parasitose devida a esse protozoário, considerando que ela é mais proeminente sob o ponto de vista médico-assistencial. A propósito, efetuamos apreciações baseadas em modelo...
Evaluation of therapeutic activity of albendazole against experimental and huma...
Amato Neto, Vicente; Moreira, Antonio Augusto Baillot; Ferreira, Graça Maria Pinto; Nascimento, Sérgio Antonio Barbosa do; Matsubara, LuísWith the objective of knowing adequately the spectrum of activity of albendazole against intestinal helminthiases, we made observations regarding hymenolepiasis caused by Hymenolepis nana. Two series of investigations were carried out: a) treatment of mice with single doses of either 25 or 50 mg/kg, repeated after ten days, using as controls animals treated with 25 mg/kg of praziquantel or not treated with any ...
Observations on the viability of Trypanosoma cruzi in sugar cane juice
Pinto, Pedro Luiz Silva; Amato Neto, Vicente; Nascimento, Sérgio Antonio Barbosa do; Souza, Hertha Barbara Wüllert Telles de; Miyamoto, AkimiIn Catolé do Rocha, State of Paraíba, Brasil several people were concomitantly contaminated by Chagas' disease and had the acute form of the infection. Because of this event, the hypothesis that Trypanosoma cruzi might have been transmitted by the digestive route, through the ingestion of accidentally contaminated sugar cane juice, was made. In the present study, we verified that the parasite has remained viabl...
Therapy of the experimental infection by Strongyloides venezuelensis in rats wi...
Campos, Rubens; Pinto, Pedro Luiz Silva; Amato Neto, Vicente; Matsubara, Luís; Miyamoto, Akimi; Carvalho, Silvino Alves de; Takiguti, Clóvis KiomitsuFor the therapy of human strongyloidiasis, are necessary effective drugs to eliminate both larvae and adult worm parasitism, which may also be used by parenteral route, to obviate the particular conditions presented by many patients. A study based on the experimental infection by Strongyloides venezuelensis in rats was done, administering injectable ivermectin or levamizole. Both drugs were shown to be active, ...
"In vitro" activity of gentian violet against asexual Plasmodium falciparum par...
Yang, Shen Lin; Di Santi, Silvia Maria; Amato Neto, Vicente; Moreira, Antonio Augusto Baillot; Pinto, Pedro Luiz Silva; Boulos, Marcos; Campos, RubensIn order to investigate whether gentian violet exhibited "in vitro" inhibitory activity against Plasmodium falciparum, the Authors have carried out 20 sensitivity tests according to the microtechnique described by RIECK MANN et al.5. Results have shown inhibition of schizonts'maturation at the following concentration: 1/1000; 1/1500; 1/2000; 1/2500; 1/3000 and 1/4000, thus demonstrating inhibitory activity of t...
Avaliação da atividade terapêutica do albendazol em ratos experimentalmente inf...
Amato Neto, Vicente; Pinto, Pedro Luiz Silva; Moreira, Antonio Augusto Baillot; Campos, Rubens; Sant'ana, Eunice José de; Levai, Eduardo VirgilioIn order to settle the precise spectrum of activity of albendazole, its efficacy was tested in the treatment of Strongyloides venezuelensis in experimentally-infected rats. The results were compared to those obtained with two other benzimidaloze derivatives, cambendazole and mebendazole. The three compounds were shown to be effective in eradicating intestinal adult worms completely, when single doses of 625, 12...
Experimental study on the possible profilatic action of the gentian's violet in...
Pinto, Pedro Luiz Silva; Amato Neto, Vicente; Duarte, Maria Irma Seixas; Cotrim, José Xavier; Moreira, Antonio Augusto Baillot; Sant'ana, Eunice José deDevido a evidências sugestivas da possibilidade de transmissão da toxoplasmose por transfusão de sangue, os autores se propuseram avaliar o papel preventivo da violeta de genciana, à semelhança do que já é estabelecido para a doença de Chagas. O experimento em camundongos revelou a ação profilática da violeta de genciana quando adicionado ao sangue a ser transfundido na concentração de 1/1000 e permanência por ...
Assessment of the antihelminthic activity of albendazole in human strongyloidiasis
Amato Neto, Vicente; Moreira, Antonio Augusto Baillot; Chiaramelli, Maria Cecília Glanizella; Leme, José Mauro Torres Paes; Chiaramelli, Domingos RomeroA new antihelminthic agent, albendazole, was used in the treatment of 32 patients with strongyloidiasis. This trial included male and female adults, who were given 400 mg daily, as a single oral dose, for three days. The cure rates were assessed by stool examination performed according to the Rugai, Mattos and Brisola technique, with samples obtained seven, 14 and 21 days after the final dose of the drug. A mea...