17 documents found, page 1 of 2
A potential link among antioxidant enzymes, histopathology, and trace elements ...
Souza, Carolina Carvalho de; Barreto, Tatiane Oliveira; Silva, Sydnei Magno da; Pinto, Aldair Junio Woyames; Figueiredo, Maria MartaCanine visceral leishmaniasis (CVL) is a severe and fatal systemic chronic inflammatory disease. We investigated the alterations in, and potential associations among, antioxidant enzymes, trace elements and histopathology in CVL. Blood and tissue levels of Cu-Zn superoxide dismutase, catalase and glutathione peroxidase were measured in mixed-breed dogs naturally infected with Leishmania infantum chagasi, sympto...
Early infection with Leishmania major restrains pathogenic response to Leishman...
Lombana, Claudia Zuleida Gonzalez; Santiago, Helton da Costa; Macedo, J. P.; Rego, Virgínia Aparecida Seixas; Russo, Remo de Castro; Tafuri, Wagner LuizExperimental models of infection with Leishmania spp. have provided knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite growth. It is well accepted that concomitant immunity exists, and there is some evidence that it would play a major role in long-lasting acquired resistance to infection. In this paper, the resistance to Leishmania amazonensis in...
Vaccine-induced protection against Leishmania amazonensis is obtained in the ab...
Sabioni, Mayra Xiomara Hernández; Baçante, Thales Augusto; Vilela, Luciano; Tafuri, Wagner Luiz; Afonso, Luís Carlos Crocco; Vieira, Leda QuerciaProtozoa of the genus Leishmania are intracellular parasites of macrophages and may cause diverse clinical forms of leishmaniasis, including cutaneous, diffuse cutaneous, mucocutaneous and visceral leishmaniasis. Infection with L. major in mice indicates that a protective immune response is achieved when Th1 cells are developed. Thus, adoptive or vaccine-induced protection against leishmaniasis is largely depen...
Ecto-nucleotidase activities of promastigotes from leishmania (Viannia) brazili...
Leite, Pauline Martins; Gomes, Rodrigo Saar; Figueiredo, Amanda Braga de; Serafim, Tiago Donatelli; Tafuri, Wagner Luiz; Gomes, Carolina CavaliériBackground: Leishmania (Viannia) braziliensis has been associated with a broad range of clinical manifestations ranging from a simple cutaneous ulcer to destructive mucosal lesions. Factors leading to this diversity of clinical presentations are not clear, but parasite factors have lately been recognized as important in determining disease progression. Given the fact that the activity of ecto-nucleotidases corr...
Short-term protection conferred by Leishvacin® against experimental Leishmania ...
Carneiro, Matheus Batista Heitor; Sousa, Louisa Maria de Andrade e; Vaz, Leonardo Gomes; Santos, Liliane Martins dos; Vilela, LucianoTo date, there is no vaccine available against human leishmaniasis. Although some vaccination protocols can induce immunity in murine models, they fail to induce protection in humans. The reasons for that remain unclear. The aimof the present study was to characterize the changes in the pattern of the immune response during subcutaneous vaccination with Leishvacin® in mice. We also investigated whether IFN-γ an...
CD8þT cells are not required for vaccine-induced immunity against Leishmania am...
Hernández Sanabria, Mayra Xiomara; Afonso, Luís Carlos Crocco; Golgher, Denise; Tafuri, Wagner Luiz; Vieira, Leda QuerciaVaccine-induced protection against leishmaniasis is largely dependent on cell-mediated type 1 response and IL-12-driven IFN-g production. Surprisingly, our previous data showed that IL-12/23p40_/_ mice could be vaccinated against L. amazonensis and were able to produce limited amounts of IFN-g. Since the role of CD8þT in immunization against L. amazonensis is obscure, the aim of this study was to evaluate the e...
Histopathological findings and detection of parasites in the eyes of dogs infec...
Brito, Fábio Luiz da Cunha; Laus, José Luiz [UNESP]; Tafuri, Wagner Luiz; Figueiredo, Maria Marta; Silva Júnior, Valdemiro AmaroSubmitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:00:12Z No. of bitstreams: 1 S0103-84782010000500022.pdf: 196691 bytes, checksum: 4a2839f9a86844112337d299323b3d30 (MD5); Made available in DSpace on 2013-08-22T19:00:12Z (GMT). No. of bitstreams: 1 S0103-84782010000500022.pdf: 196691 bytes, checksum: 4a2839f9a86844112337d299323b3d30 (MD5) Previous issue date: 2010-05-01; Made availabl...
American tegumentary leishmaniasis : effectiveness of an immunohistochemical pr...
Alves, Cibele Fontes; Alves, Cíntia Fontes; Figueiredo, Maria Marta; Souza, Carolina Carvalho de; Coelho, George Luiz Lins Machado; Melo, Maria NormaBackground: American tegumentary leishmaniasis (ATL) is endemic in Latin America, where Brazil has over 27 thousand cases per year. The aim of the present study was to develop an immunohistochemical method (IHC) for ATL diagnosis. For this purpose, we used serum from a dog naturally infected with Leishmania (L) infantum (canine hyperimmune serum) as the primary antibody, followed by a detection system with a se...
Histopathological and immunohistochemical investigations of the hepatic compart...
Giunchetti, Rodolfo Cordeiro; Mayrink, Wilson; Carneiro, Cláudia Martins; Oliveira, Rodrigo Corrêa de; Martins Filho, Olindo Assis; Marques, Marcos JoséThe immunopathological evaluation of the hepatic compartment associated with parasitism and biochemical findings are essential for understanding the genesis of hepatomegaly in anine visceral leishmaniasis (CVL). Three clinical groups of dogs naturally infected with Leishmania chagasi[i.e., asymptomatic (AD, n = 12), oligosymptomatic (OD,n = 12) and symptomatic (SD,n = 17)] were assessed and compared with a grou...
Trypanosoma cruzi : immunoglobulin isotype profiles during the acute phase of c...
Vital, Wendel Coura; Carneiro, Cláudia Martins; Martins, Helen Rodrigues; Lana, Marta de; Veloso, Vanja Maria; Carvalho, Andréa Teixeira deA detailed investigation has been carried out about the serological profiles of groups of dogs experimen-tally infected with metacyclic (MT) or blood (BT) trypomastigotes of Berenice-78 Trypanosoma cruzi strain. Peripheral blood was collected from infected dogs and uninfected controls, weekly during 35 days following the acute phase of infection, and immunoglobulin profiles were determined by ELISA. Dogs infect...