2 documents found, page 1 of 1
The dynamic conformational landscape of the protein methyltransferase SETD8
Shi Chen; Wiewiora, Rafal P.; Fanwang Meng; Babault, Nicolas; Anqi Ma; Wenyu Yu; Kun Qian; Hao Hu; Hua Zou; Junyi Wang; Shijie Fan; Blum, GilElucidating the conformational heterogeneity of proteins is essential for understanding protein function and developing exogenous ligands. With the rapid development of experimental and computational methods, it is of great interest to integrate these approaches to illuminate the conformational landscapes of target proteins. SETD8 is a protein lysine methyltransferase (PKMT), which functions in vivo via the met...
Redefining the MED13L syndrome
Lopes, Fátima Daniela Teixeira; Adegbola, Abidemi; Musante, Luciana; Maciel, P.; Hao Hu; Isidor, Bertrand; Picker-Minh, Sylvie; Caignec, Cedric LeCongenital cardiac and neurodevelopmental deficits have been recently linked to the mediator complex subunit 13-like protein MED13L, a subunit of the CDK8-associated mediator complex that functions in transcriptional regulation through DNA-binding transcription factors and RNA polymerase II. Heterozygous MED13L variants cause transposition of the great arteries and intellectual disability (ID). Here, we report ...