12 documents found, page 1 of 2
Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: E...
Taheri, Y; Sharifi-Rad, J; Antika, G; Yilmaz, YB; Tumer, TB; Abuhamdah, S; Chandra, S; Saklani, S; Kiliç, CS; Sestito, S; Dastan, SD; Kumar, MLuteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, a...
Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Mole...
Sharifi-Rad, J; Martins, N; López-Jornet, P; Lopez, EPF; Harun, N; Yeskaliyeva, B; Beyatli, A; Sytar, O; Shaheen, S; Sharopov, F; Taheri, Y; Docea, AOCoumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensi...
Cyperus spp.: A Review on Phytochemical Composition, Biological Activity, and H...
Taheri, Y; Herrera-Bravo, J; Huala, L; Salazar, LA; Sharifi-Rad, J; Akram, M; Shahzad, K; Melgar-Lalanne, G; Baghalpour, N; Tamimi, KCyperaceae are a plant family of grass-like monocots, comprising 5600 species with a cosmopolitan distribution in temperate and tropical regions. Phytochemically, Cyperus is one of the most promising health supplementing genera of the Cyperaceae family, housing ˜950 species, with Cyperus rotundus L. being the most reported species in pharmacological studies. The traditional uses of Cyperus spp. have been report...
Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
Ayatollahi, SA; Sharifi-Rad, J; Tsouh Fokou, PV; Mahady, GB; Ansar Rasul Suleria, H; Krishna Kapuganti, S; Gadhave, K; Giri, R; Garg, N; Sharma, RThe current coronavirus disease (COVID-19) outbreak is a significant threat to human health and the worldwide economy. Coronaviruses cause a variety of diseases, such as pneumonia-like upper respiratory tract illnesses, gastroenteritis, encephalitis, multiple organ failure involving lungs and kidneys which might cause death. Since the pandemic started there have been more than 107 million COVID-19 infections ca...
Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Dis...
Quispe, C; Martins, N; Manca, ML; Manconi, M; Sytar, O; Hudz, N; Shanaida, M; Kumar, M; Taheri, Y; Martorell, M; Sharifi-Rad, J; Pintus, G; Cho, WCDue to its vast therapeutic potential, the plant-derived polyphenol curcumin is utilized in an ever-growing number of health-related applications. Here, we report the extraction methodologies, therapeutic properties, advantages and disadvantages linked to curcumin employment, and the new strategies addressed to improve its effectiveness by employing advanced nanocarriers. The emerging nanotechnology application...
Curcumin’s nanomedicine formulations for therapeutic application in neurologica...
Salehi, B; Calina, D; Docea, AO; Koirala, N; Aryal, S; Lombardo, D; Pasqua, L; Taheri, Y; Castillo, CMS; Martorell, M; Martins, N; Iriti, MThe brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid ß-binding, anti-inflammatory, tau inhibition, metal chelation, ne...
Myricetin bioactive effects: Moving from preclinical evidence to potential clin...
Taheri, Y; Suleria, HAR; Martins, N; Sytar, O; Beyatli, A; Yeskaliyeva, B; Seitimova, G; Salehi, B; Semwal, P; Painuli, S; Kumar, A; Azzini, ESeveral flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the neuroprotective activity, showing preclinical activities on Alzheimer, Parkinson, and Huntington diseases, and even in amyotrophic lateral sclerosis. Also, myricet...
Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardiop...
Sharifi-Rad, J; Rodrigues, CF; Sharopov, F; Docea, AO; Karaca, AC; Sharifi-Rad, M; Karincaoglu, DK; Gülseren, G; Senol, E; Demircan, E; Taheri, YHeart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumpti...
Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safet...
Sharifi-Rad, J; Rayess, YE; Rizk, AA; Sadaka, C; Zgheib, R; Zam, W; Sestito, S; Rapposelli, S; Neffe-Skocinska, K; Zielinska, D; Salehi, B; Setzer, WNCurcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin application...
Therapeutic potential of a-and ß-pinene: A miracle gift of nature
Salehi, B; Upadhyay, S; Orhan, IE; Jugran, AK; Jayaweera, SLD; Dias, D; Sharopov, F; Taheri, Y; Martins, N; Baghalpour, N; Cho, WC; Sharifi-Rad, Ja-and ß-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of ...