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Synthesis, molecular properties prediction and cytotoxic screening of 3-(2-aryl...
Maia, Angélica Faleiros da Silva; Siqueira, Raoni Pais; Oliveira, Fabrício Marques de; Ferreira, Joana Gasperazzo; Silva, Silma Francielle daIn the present investigation, a collection of nineteen 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones was synthesized and screened for their cytotoxic activity against a panel of three leukemia cancer cell lines. The compounds were prepared via ZrOCl2·8H2O catalyzed condensation reactions between phthalaldehydic acid and different acetophenones. The reactions were carried out free of solvent and the isobenzofura...
Data: 2018
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Origem: Oasisbr