3 documents found, page 1 of 1
Leveraging machine learning techniques to investigate the pathogenesis of incid...
Elnaggar, J.; Jacobs, C.; Ardizzone, C.; Aaron, K.; Eastlund, I.; Graves, K.; Luo, M.; Tamhane, A.; Long, D.; Laniewski, P.; Herbst-Kralovetz, M.Objective We investigated longitudinal changes in the vaginal microbiota prior to, during, and immediately following the onset of incident bacterial vaginosis (iBV) to investigate its pathogenesis. We used supervised machine learning and artificial neural networks (ANNs) to identify vaginal micro-organisms predictive of future iBV development. Study Design In this prospective cohort study, we performed 16S rRNA...
Longitudinal analysis of select bacterial species composition among women with ...
George, S.; Dong, C.; Aaron, K.; Sherman, A.; Van Gerwen, O.; Tamhane, A.; Taylor, C.; Sousa, Lúcia Filipa Guimarães Vieira; Almeida, C.; Cerca, NunoObjective Key BV-associated bacteria that may be important in incident BV (iBV) pathogenesis are Gardnerella species and Prevotella bivia. We quantified the amount of these bacterial species in clue cell biofilms in longitudinal vaginal specimens from iBV cases and controls using peptide nucleic acid fluorescence in situ hybridization (PNA-FISH). Study Design Women with optimal vaginal microbiota self-collected...
Incident bacterial vaginosis in a community-based cohort of women
Muzny, C.; Aaron, K.; Tamhane, A.; Long, D.; Van Gerwen, O.; Graves, K.; Eastlund, I.; Elnaggar, J.; Cerca, Nuno; Taylor, C.[Excerpt] OBJECTIVES: ln an ongoing community-based BV pathogenesis study, we evaluated time to incident BV (iBV) as well as select characteristics of women with this infection. METHODS: Non-pregnant women ages 18-45 with normal vaginal microbiota (no Amsel criteria, normal Nugent score), no antibiotic use in the past 14 days, no concurrent STis, and a current male sexual partner were followed for 9 weeks. Part...