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Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in chil...
Pereira,Patrícia de Araújo; Alvim-Soares Jr.,António Marcos; Sandrim,Valéria Cristina; Lanna,Carla Márcia Moreira; Souza-Costa,Débora CristineAbstract Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures...
Papel do óxido nítrico na regulação da circulação pulmonar: implicações fisioló...
Dias-Junior,Carlos Alan; Cau,Stefany Bruno de Assis; Tanus-Santos,José EduardoO nitric oxide (NO, óxido nítrico) é um mediador endógeno vasoativo que contribui para a homeostase vascular pulmonar. O NO é produzido por três isoformas das nitric oxide synthases (NOS, óxido nítrico sintases)-NOS neuronial (nNOS); NOS induzida (iNOS); e NOS endotelial (eNOS)-estando as três presentes no pulmão. Estudos que utilizaram inibidores farmacológicos ou camundongos knockout têm demonstrado que o NO ...
A critical review of biomarkers used for monitoring human exposure to lead: adv...
Barbosa Jr,Fernando; Tanus-Santos,José Eduardo; Gerlach,Raquel Fernanda; Parsons,Patrick J.Lead concentration in whole blood (Blood-Pb) is the primary biomarker used to monitor exposure to this metallic element. However, the difficulty in assessing the exact nature of Pb exposure is dependent not so much on problems with current analytical methodologies, but rather on the complex toxicokinetics of Pb within various body compartments. If we are to differentiate more effectively between Pb that is stor...