11 documents found, page 1 of 2
Immunomodulatory inhibition of osteoclastogenesis by a marine microalgal ethano...
Carletti, Alessio; Pes, Katia; Tarasco, Marco; Rosa, Joana; Poudel, Sunil; Pereira, Hugo; Louro, Bruno; Cancela, M. Leonor; Laizé, VincentBackground: Targeting immune pathways to prevent bone loss represents a promising, yet underexplored therapeutic strategy. Methods: An ethanol-soluble fraction derived from the freeze-dried biomass of the marine microalga Skeletonema costatum (SKLT) was tested for its ability to modulate immune responses and inhibit osteoclastogenesis. Its effects were evaluated in a zebrafish model of bone regeneration, a meda...
Effects of pristine or contaminated polyethylene microplastics on zebrafish dev...
Tarasco, Marco; Gavaia, Paulo; Bensimon-Brito, Anabela; Cordelières, Fabrice P.; Santos, Tamara; Martins, Gil; De Castro, Daniela; Silva, NadiaThe presence of microplastics in the aquatic ecosystem represents a major issue for the environment and human health. The capacity of organic pollutants to adsorb onto microplastic particles raises additional concerns, as it creates a new route for toxic compounds to enter the food web. Current knowledge on the impact of pristine and/or contaminated microplastics on aquatic organisms remains insufficient, and w...
How microplastics and adsorbed pollutants affect zebrafish development?
Tarasco, MarcoA presença de microplásticos no ecossistema aquático é, nos dias de hoje, uma realidade extremamente preocupante que acarreta sérios riscos para o meio ambiente e para a saúde pública. A capacidade dos microplásticos de adsorverem poluentes orgânicos, como é o caso do benzo[α]pireno (BaP), levanta preocupações adicionais, pois cria uma nova rota de entrada de compostos tóxicos na cadeia alimentar. No entanto, o...
Screening of mineralogenic and osteogenic compounds in zebrafish—tools to impro...
Rosa, Joana; Tarasco, Marco; J. Gavaia, Paulo; Leonor Cancela, M.; Laizé, VincentBone disorders affect millions of people worldwide and treatments currently available often produce undesirable secondary effects or have limited efficacy. It is therefore of the utmost interest for patients to develop more efficient drugs with reduced off-target activities. In the long process of drug development, screening and preclinical validation have recently gained momentum with the increased use of zebr...
New insights into benzo[⍺]pyrene osteotoxicity in zebrafish
Tarasco, Marco; Gavaia, Paulo; Bensimon-Brito, Anabela; Cardeira-da-Silva, João; Ramkumar, Srinath; Cordelières, Fabrice P.; Günther, StefanPersistent and ubiquitous organic pollutants, such as the polycyclic aromatic hydrocarbon benzo[⍺]pyrene (BaP), represent a major threat to aquatic organisms and human health. Beside some well-documented adverse effects on the development and reproduction of aquatic organisms, BaP was recently shown to affect fish bone formation and skeletal development through mechanisms that remain poorly understood. In this ...
Antioxidant, mineralogenic and osteogenic activities of Spartina alterniflora a...
Roberto, Vania Palma; Surget, Gwladys; Le Lann, Klervi; Mira, Sara; Tarasco, Marco; Guérard, Fabienne; Poupart, Nathalie; Laizé, VincentOsteoporosis is an aging-related disease and a worldwide health issue. Current therapeutics have failed to reduce the prevalence of osteoporosis in the human population, thus the discovery of compounds with bone anabolic properties that could be the basis of next generation drugs is a priority. Marine plants contain a wide range of bioactive compounds and the presence of osteoactive phytochemicals was investiga...
ZEB316: a small stand-alone housing system to study microplastics in small tele...
Tarasco, Marco; Martins, Gil; Gavaia, Paulo; Bebianno, Maria; Leonor Cancela, M.; Laizé, VincentMany anthropogenic chemicals and plastic debris end up in the aquatic ecosystem worldwide, representing a major concern for the environment and human health. Small teleosts, such as zebrafish (Danio rerio) and Japanese medaka (Oryzias latipes), offer significant advantages over classical animal models and are currently used as first-line organisms to assess environmental risks associated with many aquatic toxic...
ZFBONE: an ImageJ toolset for semi-automatic analysis of zebrafish bone structures
Tarasco, Marco; Cordelieres, Fabrice P.; Cancela, M. Leonor; Laizé, VincentThe last decade has seen an increased interest in the discovery of compounds with bone anabolic activity to treat skeletal disorders such as osteoporosis and increase the well-being of patients. Due to the many technical advantages over classical rodent systems, zebrafish (Danio rerio) has been increasingly used in screening pipelines, in particular those aiming at identifying osteoactive compounds with pharmac...
Anti-osteogenic activity of cadmium in zebrafish
Tarasco, Marco; Cardeira Da Silva, João; Viegas, Michael; Caria, Joana; Martins, Gil; Gavaia, Paulo; Cancela, M. Leonor; Laizé, VincentAmong the many anthropogenic chemicals that end up in the aquatic ecosystem, heavy metals, in particular cadmium, are hazardous compounds that have been shown to affect developmental, reproductive, hepatic, hematological, and immunological functions in teleost fish. There is also evidence that cadmium disturbs bone formation and skeletal development, but data is scarce. In this work, zebrafish was used to furth...
The zebrafish operculum: a powerful system to assess osteogenic bioactivities o...
Tarasco, Marco; Laizé, Vincent; Cardeira, João; Leonor Cancela, M.; Gavaia, PauloBone disorders affect millions of people worldwide and available therapeutics have a limited efficacy, often presenting undesirable side effects. As such, there is a need for novel molecules with bone anabolic properties. The aim of this work was to establish a rapid, reliable and reproducible method to screen for molecules with osteogenic activities, using the zebrafish operculum to assess bone formation. Expo...