3 documents found, page 1 of 1
Natural Killer T-like Cells: Immunobiology and Role in Disease
Almeida, Jani-Sofia; Casanova, José M.; Santos-Rosa, Manuel; Tarazona, Raquel; Solana, Rafael; Rodrigues-Santos, PauloCD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview of what is currently known, we reviewed the literature on human NKT-like cells. NKT-like cells are highly differe...
NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Ty...
Almeida, Jani Sofia; Couceiro, Patrícia; López-Sejas, Nelson; Alves, Vera; Růžičková, Lenka; Tarazona, Raquel; Solana, Rafael; Tavares, PauloTherapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their association with inflammation, autoimmune diseases, and cancer. Since the information regarding the ro...
Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treat...
Rodrigues-Santos, Paulo; López-Sejas, Nelson; Almeida, Jani-Sofia; Ruzičková, Lenka; Couceiro, Patrícia; Alves, Vera; Campos, Carmen; Alonso, CoronaNatural killer (NK) cells are a very important component of the innate immune response involved in the lysis of virus infected and tumor cells. Aging has a profound impact in the frequency, phenotype and function of NK cells. Chronic Myeloid Leukemia (CML) is caused by the BCR-ABL gene formation encoding aberrant oncoprotein tyrosine kinase. Treatment with tyrosine kinase inhibitors (TKIs) induces durable deep ...